Abstract: We conducted this research to determine the NAT2 gene-phenotype characteristics and pharmacokinetics (PK) parameters of isoniazid among patients with non-MDR pulmonary tuberculosis. Data were collected from 132 diagnosed newly acquired or relapsed tuberculosis treated at 03 hospitals: Hanoi Lung Hospital, Central National K74 Hospital. PK samples one day 10th – 14th after commencing t...

Sulindac is a prescription-based non-steroidal anti-inflammatory drug (NSAID) that continues to be actively investigated as a candidate cancer chemoprevention agent. To further current understanding of sulindac bioavailability, metabolism, and disposition, we developed a population pharmacokinetic model for the parent compound and its active metabolites, sulindac sulfide, and exisulind. This an...

AIM Dolutegravir is the newest integrase inhibitor approved for HIV treatment and has demonstrated potent antiviral activity in patient populations with a broad range of treatment experience. This analysis aimed to characterize the population pharmacokinetics of dolutegravir in treatment-naive patients and to evaluate the influence of patient covariates. METHODS A population pharmacokinetic m...

tetracycline may be used to treat several types of bacterial diseases in ruminants. in addition, tetracycline is added to food to promote the growth. there are few reports on the pharmacokinetics of tetracycline in sheep. therefore, the objective of this study was to examine the pharmacokinetic characteristics of the drug in sheep. ten apparently healthy mixed-breed sheep were administered 20 m...

fluconazole is commonly used both to prevent and to treat invasive neonatal candida albicans infection. this drug is a potent, selective, triazole inhibitor of the fungal enzymes involved in ergosterol synthesis. it is largely excreted unchanged in the urine. in infants with a birth weight <1,500 grams, fungal infection is approximately 3% to 4%. up to 30% of infants with invasive candidiasis d...

tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. to date, there is no information on the pharmacokinetics of tacrolimus in iranian liver transplant recipients. this study was designed to determine pharmacokinetic properties of orally administe...

BACKGROUND AND OBJECTIVES Dasotraline is a novel inhibitor of dopamine and norepinephrine reuptake currently being investigated in clinical studies for the treatment of attention-deficit/hyperactivity disorder (ADHD). Uniquely, relative to current ADHD medications, dasotraline has a slow absorption and long elimination half-life. Here we relate the pharmacokinetics and pharmacodynamics of dasot...