Abstract Inhaled glucocorticoids (GCs) are the first-line treatment for asthma. However, patients with asthma characterized by recruitment of neutrophils show poor sensitivity to GC therapy. A potential etiology this GC-resistant is aerosolized cyanobacterial lipopolysaccharide (LPS) from blooms. Previously, we demonstrated that inhalation LPS Geitlerinema sp. cyanobacteria induces neutrophilic...

BACKGROUND In Japan, the number of asthma deaths has been gradually decreasing. However, in the management of asthma, there are still some problems originating from patient-related factors and iatrogenic factors, both of which should be further analyzed. METHODS We investigated clinical and background characteristics of 164 patients with asthma who were admitted to our hospital with acute exa...

In this short report, we reviewed the literature on the consequences of poor compliance in chronic respiratory diseases. Unquestionably, poor compliance is a very significant medical issue in the management of tuberculosis. Poor compliance could cause serious personal and public health problems and is probably the major obstacle to the elimination of tuberculosis. Similarly, important consequen...

BACKGROUND Poor asthma outcomes often result from patients not following physician medication recommendations (ie, nonadherence). Estimates suggest that 50% of patients with asthma do not follow physician medication recommendations. OBJECTIVE To examine the rationale for making available objective medication adherence monitors for physicians to improve the quality of care for patients with se...

T he treatment of eczema in the pediatric population can be a complex and dynamic process. A typical careplanmay includeover-the-counter andprescription topical agents, oral medications, as well as bathing and dietary recommendations. Inevitable disease fluctuations demand treatment modification, and thus parental and patient confusion can easily occur. Not surprisingly, adherence in eczema man...

allergic asthma is a complex and chronic inflammatory airway disease. interleukin-17 is a pro-inflammatory cytokine which plays critical role in the pathogenesis of allergic asthma. it has been reported that β-arrestin2 regulated the development of allergic asthma at a proximal step in the inflammatory cascade. in this study, the influence of β-arrestin2 on interleukin-17 production and express...

INTRODUCTION Current practice guidelines provide recommendations for the optimal management and control of asthma. However, the implementation of the recommendations in specific areas needs to be adapted to local conditions. No data on the burden of asthma and on the quality of asthma treatment and control are currently available in Lebanon. This study was therefore conducted to determine how c...

99 On the basis of knowledge that asthma is a chronic inflamma-tory disorder of the airways, evidence-based practice guidelines have recommended anti-inflammatory controller therapy to improve asthma outcomes during the past 3 decades. Recently published guidelines have emphasized the role of anti-inflammatory maintenance therapy to prevent chronic persistence and troublesome exacerbations of a...

BACKGROUND Asthma undertreatment has been linked to poor outcomes. National guidelines recommend that physicians classify asthma severity based on pretreatment symptoms and titrate care as the disease changes in the individual patient. This study evaluated the extent to which the physician estimate of underlying severity affects a patient's asthma care. METHODS Data used were collected from a...

background: high prevalence and increasing rate of asthmatic patients around the word witnesses the high burden of asthma. we have limited data on asthma burden and economic costs in iran. this study aimed to find direct and indirect economic costs of asthma and their association with some background factors in one of the referral tertiary centers for adult patients with asthma. methods: we sur...