نتایج جستجو برای: polymorphism il6

تعداد نتایج: 109750  

Journal: :Molecular human reproduction 2012
Sharon L Eddie Andrew J Childs Henry N Jabbour Richard A Anderson

Fetal ovarian development and primordial follicle formation are imperative for adult fertility in the female. Data suggest the interleukin (IL)6-type cytokines, leukaemia inhibitory factor (LIF), IL6, oncostatin M (OSM) and ciliary neurotrophic factor (CNTF), are able to regulate the survival, proliferation and differentiation of fetal murine germ cells (GCs) in vivo and in vitro. We postulated...

Journal: :The Journal of infectious diseases 2012
Ana Lucia M Sousa Vinicius M Fava Lucas H Sampaio Celina Maria T Martelli Mauricio B Costa Marcelo T Mira Mariane M A Stefani

In leprosy, type 1 reaction (T1R) and type 2 reaction (T2R) are major causes of nerve injury and permanent disabilities. A previous study on plasma levels of 27 cytokines in patients with T1R or T2R and controls with nonreactional leprosy identified the gene for interleukin 6 (IL-6) as a candidate for genetic analysis. Two nested case-control studies were built from a cohort of 409 patients wit...

Journal: :Cancer immunology research 2015
Andrea M Griesinger Rebecca J Josephson Andrew M Donson Jean M Mulcahy Levy Vladimir Amani Diane K Birks Lindsey M Hoffman Steffanie L Furtek Phillip Reigan Michael H Handler Rajeev Vibhakar Nicholas K Foreman

Ependymoma (EPN) in childhood is a brain tumor with substantial mortality. Inflammatory response has been identified as a molecular signature of high-risk Group A EPN. To better understand the biology of this phenotype and aid therapeutic development, transcriptomic data from Group A and B EPN patient tumor samples, and additional malignant and normal brain data, were analyzed to identify the m...

Journal: :In vivo 2014
Timothy R McGuire Nicole T Reardon Kimberly Bogard Troy J Plumb Chris J Bultsma Steve W Nissen Patrick D Fuller Keith M Olsen

BACKGROUND The present study evaluated interleukin-6 (IL6) as a predictor of mortality in patients and sepsis with acute kidney injury (AKI) receiving sustained low-efficiency dialysis (SLED) and antibiotic therapy. PATIENTS AND METHODS Seven patients with sepsis receiving antibiotics and SLED for AKI were studied. Blood was obtained at baseline prior to SLED and antibiotics, during SLED, and...

Journal: :Postgraduate medical journal 2005
E Unsal S Aksaray D Köksal T Sipit

OBJECTIVE Reactive thrombocytosis is found in a number of clinical situations including infectious diseases such as pulmonary tuberculosis (PTB). To examine the possible role of interleukin (IL6) in reactive thrombocytosis and acute phase response in PTB this study measured serum IL6, C reactive protein (CRP), erythrocyte sedimentation rate (ESR), albumin concentrations in 62 PTB patients and 2...

Journal: :Experimental & clinical gastroenterology 2023

Purpose of the study. To study distribution and role polymorphic loci cytokine gene IL6 (C174G) in inflammatory ulcerative lesions stomach. Material research methods. In this study, detection was carried out patients with stomach (n=96) healthy individuals (n=88). Results. Analysis features polymorphism among studied groups diseases compared ones, its contribution to pathogenetic mechanisms the...

2012
S. Gregersen D. Samocha-Bonet L. K. Heilbronn L. V. Campbell

The postprandial state is hypothesised to be proinflammatory and prooxidative, but the relative contributions of fat versus carbohydrate are unclear. Therefore, we examined inflammation and oxidative stress responses in serum and skeletal muscle before and after 1000 kcal meals, which were high in either fat or carbohydrate in 15 healthy individuals. Serum and muscle expression of IL6 was eleva...

Journal: :Molecular cell 2012
Hasan Korkaya Gwang-Il Kim April Davis Fayaz Malik N Lynn Henry Suthinee Ithimakin Ahmed A Quraishi Nader Tawakkol Rosemarie D'Angelo Amanda K Paulson Susan Chung Tahra Luther Hayley J Paholak Suling Liu Khaled A Hassan Qin Zen Shawn G Clouthier Max S Wicha

Although inactivation of the PTEN gene has been implicated in the development of resistance to the HER2 targeting antibody trastuzumab, the mechanisms mediating this resistance remain elusive. We generated trastuzumab resistant cells by knocking down PTEN expression in HER2 overexpressing breast cancer cell lines and demonstrate that development of trastuzumab resistance in these cells is media...

Journal: :Clinical advances in hematology & oncology : H&O 2010
Frits van Rhee Katie Stone Susann Szmania Bart Barlogie Zeba Singh

Castleman disease (CD) is a nonclonal lymphoproliferative disorder that can affect single lymph node stations or, alternatively, can be generalized. Interleukin 6 (IL6) plays a pivotal role in the pathophysiology of CD. Human herpesvirus 8 (HHV8), which encodes a viral homolog of IL6, is the driving force in HIV-positive patients. The role of HHV8 in HIV-negative CD is controversial. Historical...

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