نتایج جستجو برای: polymeric prodrug
تعداد نتایج: 28114 فیلتر نتایج به سال:
Prodrugs engineered for preferential activation in diseased versus normal tissues offer immense potential to improve the therapeutic indexes (TIs) of preclinical and clinical-stage active pharmaceutical ingredients that either cannot be developed otherwise or whose efficacy tolerability it is highly desirable improve. Such approaches, however, often suffer from trial-and-error design, precludin...
Icosapent ethyl (Vazkepa) is an omega-3 fatty acid prodrug indicated for reducing the risk of cardiovascular events in statin-treated patients. This article summarises clinical trial evidence its efficacy and place therapy.
Abstract:Nanostructured titania was synthesized by colloidal and polymeric sol-gel routes. Stable colloidal and polymeric titania sols were prepared by adjusting the proper values of the acid/alkoxide and the water/alkoxide molar ratios. The properties of sols were determined by dynamic light scattering technique and synthesized titania was characterized by thermogravimetry and differential the...
Nanoparticle (NP) therapeutics have the potential to significantly alter the in vivo biological properties of the pharmaceutically active agents that they carry. Here we describe the development of a polymeric NP, termed M-NP, comprising poly(D,L-lactic-co-glycolic acid)-block-poly(ethylene glycol) (PLGA-PEG), stabilized with poly(vinyl alcohol) (PVA), and loaded with a water-soluble platinum(I...
A principal goal of cancer nanomedicine is to deliver therapeutics effectively to cancer cells within solid tumors. However, there are a series of biological barriers that impede nanomedicine from reaching target cells. Here, we report a stimuli-responsive clustered nanoparticle to systematically overcome these multiple barriers by sequentially responding to the endogenous attributes of the tum...
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