Responsive biomaterials play important roles in imaging, diagnostics, and therapeutics. Polymeric nanoparticles (NPs) containing hydrophobic and hydrophilic segments are one class of biomaterial utilized for these purposes. The incorporation of luminescent molecules into NPs adds optical imaging and sensing capability to these vectors. Here we report on the synthesis of dual-emissive, pegylated...

Nanocrystalline cellulose (NCC) is an emerging renewable nanomaterial that holds promise in many different applications, such as in personal care, chemicals, foods, pharmaceuticals, etc. By appropriate modification of NCC, various functional nanomaterials with outstanding properties, or significantly improved physical, chemical, biological, as well as electronic properties can be developed. The...

Colonic mucus is a key biological hydrogel that protects the gut from infection and physical damage and mediates host-microbe interactions and drug delivery. However, little is known about how its structure is influenced by materials it comes into contact with regularly. For example, the gut abounds in polymers such as dietary fibers or administered therapeutics, yet whether such polymers inter...

Actin exists as globular (G) monomers or polymeric filaments (F) in the cytoplasm of eukaryotic cells, mediating cell morphologic changes and motility. Large amounts of this protein may be released out to the extracellular compartment during tissue injury, but little is known about its role in biomaterial-related inflammation. We immobilized actin to methylated glass, methylated and aminated si...

The present paper proposes a novel method of quantification of the variation in biofilm architecture, in correlation with the alteration of growth conditions that include, variations of substrate and conditioning layer. The polymeric biomaterial serving as substrates are widely used in implants and indwelling medical devices, while the plasma proteins serve as the conditioning layer. The presen...

Antibiotic resistance is a crucial grievous menace to public health on a planetary scale as it plummet the effectiveness of treatment and increase morbidity and mortality (Cassandra et al., 2008). Highly resistant bacterial evolution resulted in the compromised use of new generation of antibiotics (Levy, 2002). Antibiotic resistance is due to an inherent ability of microorganism to form surface...

BI-PHASIC BIOMATERIAL AND ARTICULAR CARTILAGE E.Northwood , R.Kowalski and J.Fisher * Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK. +** DePuy CMW, Cornford Rd, Blackpool, England Email: [email protected] INTRODUCTION Natural articular cartilage has a unique biphasic lubrication regime [1]. Internal interstitial fluid pressure [2, 3] leads to low levels of fr...

This study examines in vitro and in vivo biodegradation and biocompatibility of a thermogelling polymeric material, which we call a mixture hydrogel. The mixture contains two ABA-type triblock copolymers poly(d,l-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(d,l-lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) with different block ratios, and one polymer is soluble in water, but the...

The field of biomaterials has turn into an electrifying area because these materials improve the quality and longevity of human life. The first and foremost necessity for the selection of the biomaterial is the acceptability by human body. However, the materials used in hip implants are designed to sustain the load bearing function of human bones for the start of the patient’s life. The most co...

Chitin has wide range of applications as a biomaterial, but barriers still exist to its broader use due to its physical and chemical limitations. The present study evaluated the properties of polymeric blend films obtained from chitin and bentonite (Zeolite mineral) by the casting/solvent evaporation method. The cross linking agents formaldehyde and glutaraldehyde were incorporated into the pol...