Infections caused by diverse bacteria represent a major problem that threats the health of humans. This stimulates the scientists to find new solutions for treating these diseases by clarifying the interactions of antibacterial compounds with the biological medium. In this context, the chapter presents some basic concepts regarding the antibacterial drugs. The synthesis routes of novel compound...

Platinum-based anticancer agents are widely used as first-line drugs in cancer chemotherapy for various solid tumors. However, great side effects and occurrence of resistance remain as the major drawbacks for almost all the platinum drugs developed. To conquer these problems, new strategies should be adopted for platinum drug based chemotherapy. Modern nanotechnology has been widely employed in...

It is widely held that tau determines the stability of microtubules in growing axons, although direct evidence supporting this hypothesis is lacking. Previous studies have shown that the microtubule polymer in the distal axon and growth cone is the most dynamic of growing axons; it turns over more rapidly and is more sensitive to microtubule depolymerizing drugs than the polymer situated proxim...

The explosive development of protein and peptide drugs has ushered in a great need for effective delivery systems for such drugs. Two decades of studies of protein delivery from polymeric systems has revealed the great potential of gels that respond to environmental stimuli, such as temperature, pH, etc. Protein and peptide release can be engineered to occur in a pulsatile mode. The mechanism o...

The paper focuses on the advances in the field of pain treatment by transdermal delivery of specific drugs. Starting from a short description of the skin barrier, the pharmacodynamics and pharmacokinetics including absorption, distribution, action mechanism, metabolism and toxicity, aspects related to the use of pain therapy drugs are further discussed. Most recent results on topical anesthetic...

Homogeneous distribution of poorly water-soluble drugs in polyvinylpyrrolidone (PVP), a hydrophilic carrier, is definitely a suitable way to improve the bioavailability of such drugs. However, fundamental knowledge of drug polymer interaction and comprehensive study of the thermal, structural and solubility properties of such binary systems is the prerequisite for the development of useful drug...

Natural and synthetic polymers are widely used as drug delivery tools in pharmaceutical and nanomedicine biotechnology [1-5]. Among synthetic polymers, dendrimers, a family of cationic polymers, are promising nonviral vectors for gene and drug delivery because of a well-defined molecular shape, controlled chemical structure, high water solubility, large number of chemically versatile surface gr...

Extended Abstract The microneedle mediated drug delivery system has been developed to provide painless self-administration of highpotency drug with patient friendly manner [1]. Especially, dissolving microneedles, which deliver the target drugs as the drug-loaded microneedle dissolves into the skin, have been spotlighted recently [2]. Conventional dissolving microneedles have been mostly produc...