Convergent syntheses of polyglycerol hyperbranched polymers containing fluorescent labels (fluorescein or perylene diimide (PDI)) at their core are presented. The hyperbranched polyglycerol (HPG) precursors were synthesized using a one step polymerization reaction wherein the initiator leaves a single reactive group for dye functionalization. For further site isolation, allylated HPG was synthe...

Cancer remains one of the world's most deadly diseases; with about 12 million new cases and 7.6 million cancer death every year worldwide. Despite rapid advances in diagnostic procedures and treatments, the overall survival rate fflom cancer has not improved substantially over the past 30 years. Therefore, there is a need to develop novel approaches for the accurate detection of cancer at ari e...

Superparamagnetic iron oxide nanoparticles (SPIONs) are frequently used for drug targeting, hyperthermia and other biomedical purposes. Recently, we have reported the synthesis of lauric acid-/albumin-coated iron oxide nanoparticles SEON(LA-BSA), which were synthesized using excess albumin. For optimization of magnetic treatment applications, SPION suspensions need to be purified of excess surf...

Objective(s): Over the past two decades, considerable interest has been focused on utilizing biocompatible magnetic nanoparticles (MNPs) for biomedical applications. In this study, production of human serum albumin (HSA) nanoparticles using desolvation technique that were simultaneous loaded with high amounts of superparamagnetic iron oxide nanoparticles (SPIONs) and 5-flourouracil (5-FU) was i...

Superparamagnetic iron oxide nanoparticles (SPIONs) bound directly to luteinizing hormone releasing hormone (LHRH) have shown high efficiency for intracellular uptake to breast cancer cells, MDA-MB-435S.luc. We demonstrate in this communication that inclusion of a small spacer molecule such as glutaric acid (Glu) in between SPION and LHRH increases further receptor mediated intracellular uptake...

BACKGROUND AIMS Tracking cells during regenerative cytotherapy is crucial for monitoring their safety and efficacy. Macrophages are an emerging cell-based regenerative therapy for liver disease and can be readily labeled for medical imaging. A reliable, clinically applicable cell-tracking agent would be a powerful tool to study cell biodistribution. METHODS Using a recently described chemical...

The interaction of nanoparticles (NPs) with living organisms has become a focus of public and scientific debate due to their potential wide applications in biomedicine, but also because of unwanted side effects. Here, we show that superparamagnetic iron oxide NPs (SPIONs) with different surface coatings can differentially affect signal transduction pathways. Using isogenic pairs of breast and c...

Introduction: Iron oxide nanoparticles, owing to their very small size and superparamagnetic properties, have been considered a potential candidate for several medical applications such as magnetic cell separation, magnetic resonance imaging (MRI), magnetic targeted drug delivery magnetichyperthermia. The present study aimed to synthesize and evaluate the characteristics of super...