Freeform fabrication provides an effective process tool to manufacture advanced tissue scaffolds with specific designed properties. Our research focuses on using a novel Precision Extrusion Deposition (PED) process technique to directly fabricate Polycaprolactone (PCL) and composite PCL/ Hydroxyapatite (HA) tissue scaffolds. The scaffold morphology and the mechanical properties were evaluated u...

Novel biomaterials based on hydrophilic polycaprolactone and polyurethane (Tecophilic®) nanofibers with an encapsulated 5,10,5,20-tetraphenylporphyrin photosensitizer were prepared by electrospinning. The doped nanofiber textiles efficiently photo-generate O(2)((1)Δ(g)), which oxidize external chemical and biological substrates/targets. Strong photo-virucidal effects toward non-enveloped polyom...

The study investigates the effect of polycaprolactone (PCL) concentration on metformin hydrochloride (MH) release ratio electrospun nanofiber scaffolds. Blend and emulsion electrospinning are used to produce performance nanofibrous scaffolds was evaluated by morphology (Field Emission Scanning Electron Microscopy, FESEM), chemical (Fourier Transform Infrared Spectroscopy, FTIR), thermal (Differ...

Physical properties of scaffolds intended for myocardial tissue regeneration were studied. Mechanical properties and degradation rates were evaluated for degradable scaffolds composed of poly (2-hydroxyethyl methacrylate) (pHEMA) crosslinked with polycaprolactone (PCL). pHEMA copolymerized with tetraethylene glycol as a crosslinker served as a control. Fibroblast cells were used for cytotoxicit...

Coaxial four-needle electrohydrodynamic forming is applied for the first time to prepare layered structures in both particle and fiber form. Four different biocompatible polymers, polyethylene glycol, poly (lactic-co-glycolic acid), polycaprolactone, and polymethylsilsesquioxane, are used to generate four distinct layers confirmed using transmission and scanning electron microscopy combined wit...

A new insofar as chronobiologic therapeutic approach by atrial natriuretic peptide (ANP) for hypertension and/or congestive heart failure (CHF) is based on the release of ANP from ANP cDNA transfected Chinese Hamster Ovary (CHO) cells encapsulated in polycaprolactone (PCL) tubes. ANP secretion was maintained for at least 6 months. The encapsulated cells remained viable during culturing. Control...

In bone tissue engineering, the organo-ceramic composite, electrospun polycaprolactone/hydroxyapatite (PCL/HA) scaffold has the potential to support cell proliferation, migration, differentiation, and homeostasis. Here, we report the effect of PCL/HA scaffold in tissue regeneration using human mesenchymal stem cells (hMSCs). We characterized the scaffold by fourier transform infrared spectrosco...