Polycondensation and ring-opening polymerization are two important polymer synthesis methods. Poly(lactic acid), the most typical biodegradable polymer, has been researched extensively from 1900s. It is of significant importance to have an up-to-date review on the recent improvement in techniques for biodegradable polymers. This review takes poly(lactic acid) as the example to present newly dev...

The application of poly(lactic acid) for sustained protein delivery is restricted by the harsh pH inside carriers. In this study, we synthesized a pH-responsive comb-shaped block copolymer, polyethylene glycol monomethyl ether-ε-polylysine-g-poly (lactic acid) (PEP)to deliver protein (bovine serum albumin (BSA)). The PEP nanoparticles could automatically adjust the internal pH to a milder level...

Poly (lactic-co-glycolic) acid microspheres are amenable to a number of biomedical procedures that support delivery of cells, drugs, peptides or genes. Hydrophilisation or wetting of poly (lactic-co-glycolic) acid are an important pre-requisites for attachment of cells and can be achieved via exposure to plasma oxygen or nitrogen, surface hydrolysis with NaOH or chloric acid, immersion in ethan...

Collagen and apatite were coprecipitated as a composite coating on poly L-lactic acid (PLLA) in an accelerated biomimetic process. The incubation solution contained collagen (1 g/L) and simulated body fluid with 5 times inorganic ionic concentrations as human blood plasma. The coating formed on PLLA films and scaffolds after a 24-h incubation was characterized by using energy-dispersive X-ray s...

High aspect ratio nanotubular assemblies can be effective fillers in mechanically reinforced composite materials. However, most existing nanotubes used for structural purposes are limited in their range of mechanical, chemical, and biological properties. We demonstrate an alternative approach to mechanical reinforcement of polymeric systems by incorporating synthetic D,L-cyclic peptide nanotube...

Nano/micro-plastics pollution is an emerging global concern. A variety of biodegradable polymers have been synthesized to enhance the degradation plastic materials and thereby avoid their accumulation in environment. However, even can accumulate environments under specific conditions present a potential hazard. Here, antimony sulfide-based microrobots decorated with magnetite nanoparticles are ...

AIM As a preliminary to the construction of olfactory ensheathing cells (OECs) bearing scaffold for bridging larger lesions in the spinal cord, we have investigated the response of purified cultured OECs to nanoscale fibers of varying diameter using US FDA-approved, biodegradable poly(lactic-co-glycolic-acid). MATERIALS & METHODS Conventional electrospinning produced fibers of approximately 7...

In this study, dyeing of two regenerated polyester fibers, poly-trimethylene terephthalate (PTT) and poly-lactic acid (PLA), with natural dyes were compared with that of poly-ethylene terephthalate (PET) fiber. Lac was used as the primary natural colorant while Catechu was chosen as a natural color that can also act as a biomordant. The effects of temperature, initial pH of dye bath and dyeing ...

Abstract Herein, we report the physicochemical, thermal, mechanical and biological characteristics, including bioactivity, biodegradation cytocompatibility of additive manufacturing-enabled novel nanocomposite scaffolds. The scaffolds comprise a blend polylactic acid (PLA) poly-?-caprolactone (PCL) reinforced with halloysite nanotubes (HNTs). nanoengineered filaments were developed by melt blen...

A selective electrochemical method for the determination of uric acid was developed by using nano poly cresol red modified glassy carbon electrode. This new material has been characterized by Scanning Electron Microscopy, cyclic voltammetry and Differential pulse voltammetry. This modified electrode shows excellent electrocatalytic activity towards the oxidation of uric acid in the presence of ...