Abstract Ventral hernia (VH) frequently affects patients after abdominal surgery. The use of a mesh is often recommended. Different materials are described, from synthetic non-resorbable meshes to biological meshes. New generation meshes, also named scaffolds, aim combine the advantages both materials. this review provide an overview cytological, histological, biomechanical, and clinical outcom...

The metabolic effects of a phlorizin-induced drainage of glucose were studied in six lactating ewes with or without peroral alanine drenches in a study of crossover design. Phlorizin gave rise to a small, but significant, elevation of plasma beta-hydroxybutyrate. The plasma level of alanine decreased by about 30% due to the phlorizin injections and alanine was negatively correlated to beta-hydr...

Abstract Polylactic acid (PLA) and poly(3-hydroxybutyrate- co -4-hydroxybutyrate) (P(3HB- -4HB)) nanofibers were prepared by melt extrusion of immiscible blends PLA/polyvinyl alcohol (PVA) P(3HB- -4HB)/PVA via in situ formation microfibrils during the process. The morphology after removal PVA with water was studied using scanning electron microscopy. intermolecular interactions Fourier-transfor...

Abstract Background and Aims A dysregulated energy metabolism is a key feature of Autosomal Dominant Polycystic Kidney Disease (ADPKD), characterized by cystic cells being dependent on glucose poorly able to use other sources such as ketone bodies. Besides providing energy, bodies, especially beta-hydroxybutyrate, can act signaling metabolites reduce inflammation oxidative stress. In experiment...

Based on direct sucrose conversion, the bacterium Burkholderia sacchari is an excellent producer of the microbial homopolyester poly(3-hydroxybutyrate) (PHB). Restrictions of the strain's wild type in metabolizing structurally related 3-hydroxyvalerate (3HV) precursors towards 3HV-containing polyhydroxyalkanoate (PHA) copolyester calls for alternatives. We demonstrate the highly productive bios...

Legionella pneumophila, the causative agent of Legionnaires' disease, is an intracellular parasite of eukaryotic cells. In the environment, it colonizes amoebae. After being inhaled into the human lung, the bacteria infect and damage alveolar cells in a way that is mechanistically similar to the amoeba infection. Several L. pneumophila traits, among those the Dot/Icm type IVB protein secretion ...