Inhibition of mitochondrial permeability transition pore (mPTP) opening by cyclosporin A or ischemic postconditioning attenuates lethal reperfusion injury. Its impact on major post-myocardial infarction events, including worsening of left ventricular (LV) function and death, remains unknown. We sought to determine whether pharmacological or postconditioning-induced inhibition of mPTP opening mi...

CONTEXT Sex differences in lower extremity landing mechanics and muscle activation have been identified as potential causative factors leading to the increased incidence of anterior cruciate ligament injuries in female athletes. Valgus knee alignment places greater strain on the anterior cruciate ligament than a more neutral alignment. Gluteus medius (GM) activation may stabilize the leg and pe...

In the brain, spike trains are generated in time and presumably also interpreted as they unfold in time. Recent work (Oram et al., 1999; Baker and Lemon, 2000) suggests that in several areas of the monkey brain, individual spike times carry information because they reflect an underlying rate variation. Constructing a model based on this stochastic structure allows us to apply order statistics t...

INTRODUCTION AND OBJECTIVES Cardiac resynchronization therapy is associated with improved quality of life and reduced morbidity and mortality in patients with severe ventricular dysfunction and wide QRS. However, its role in the reduction of ventricular arrhythmias is more controversial. METHODS We compared the incidence of ventricular arrhythmias in patients who were undergoing cardiac resyn...

Purpose. To develop an approach for determining the stress state of plate structural elements with holes under dynamic loads controlled accuracy. Methodology. The study was carried out on basis Laplace transform and method integral equations. Findings. An to stresses at in plates is proposed, which includes: time coordinate; a numerical transformants displacements based equations; finding origi...

Côte d’Ivoire had a strong industrial fleet both in capacity and reach. Despite the decline of the sector, the country still held a particular place within West Africa due to its harbour and shore facilities, which have made Abidjan the second most important fishing port in the region. Its industrial fleets returned to the waters of Côte d’Ivoire after West African countries declared their EEZs...

In 2010, Anderson, Craciun, and Kurtz showed that if a deterministically modeled reaction network is complex balanced, then the associated stochastic model admits a stationary distribution that is a product of Poissons [5]. That work spurred a number of followup analyses. In 2015, Anderson, Craciun, Gopalkrishnan, and Wiuf considered a particular scaling limit of the stationary distribution det...