BACKGROUND Protease nexin-1 (PN-1) is a serpin that inhibits plasminogen activators, plasmin, and thrombin. PN-1 is barely detectable in plasma, but we have shown recently that PN-1 is present within the α-granules of platelets. METHODS AND RESULTS In this study, the role of platelet PN-1 in fibrinolysis was investigated with the use of human platelets incubated with a blocking antibody and p...

Peripheral neuropathy (PN) in inflammatory bowel disease (IBD) patients has been reported as individual cases or small series; however, its clinical and electrodiagnostic features have not been well characterized. We conducted a retrospective review of patients with PN and either Crohn's disease (CD) or ulcerative colitis (UC). Eighteen patients with CD and 15 patients with UC were identified a...

The asymptotic behavior of quadratic Hermite-Padé polynomials pn, qn, rn ∈ Pn of type I and pn, qn, rn ∈ P2n of type II associated with the exponential function are studied. In the introduction the background of the definition of Hermite-Padé polynomials is reviewed. The quadratic Hermite-Padé polynomials pn, qn, rn ∈ Pn of type I are defined by the relation pn(z) + qn(z)e z + rn(z)e 2z = O(z) ...

Downlo rix metalloproteinase-9 (MMP-9) expression is known to enhance the invasion and metastasis of tumor n previous work based on a proteomic screen, we identified the serpin protease nexin-1 (PN-1) as a ial target of MMP-9. Here, we show that PN-1 is a substrate for MMP-9 and establish a link between egradation by MMP-9 and regulation of invasion. PN-1 levels increased in prostate carcinoma ...

BACKGROUND Inspiratory muscle strength in patients with neuromuscular disorders can be assessed using sniff inspiratory nasal pressure (Pn(sn)) and maximum inspiratory mouth pressure (PI(max)). However, the relative merits of Pn(sn) against PI(max) are not known in patients with severe neuromuscular disease. OBJECTIVE To investigate whether severity of disease modifies the relation between Pn...

Amongst nephron-sparing modalities, partial nephrectomy (PN) is the standard of care in the treatment of renal cell carcinoma (RCC). Despite the increasing utilization of PN, particularly propagated by robot-assisted, minimally invasive approaches for small renal masses (SRMs), the limits of PN appear to be also evolving. In this review, we sought to address the tumour stage beyond which PN may...

have infinitely many solutions. If the well known hypothesis about prime twins is true, that is, if the equation pn+i—pn — 2 has infinitely many solutions, (1) and (2) of course are trivially satisfied. The first inequality of (2) is inserted only for the sake of completeness. I t follows from the well known fact that lim sup (pn+i—pn) = °° (since n\+2, n\+3, • • • , » ! + » are all composite)....

INTRODUCTION Parenteral nutrition (PN) is an important supportive therapy. However, it is expensive and associated with significant complications. Our aim is to describe the patients given PN in 2006, to compare with the 2001 cohort and determine if PN had been prescribed for the appropriate indications. MATERIALS AND METHODS A retrospective cohort study of adult patients receiving PN between...

Although helminths induce a polarized Th2 response they have been shown, in clinical studies, to confer protection against allergies. To elucidate the basis for this paradox, we have examined the influence of an enteric helminth infection on a model of food allergy. Upon Ag challenge, mice fed peanut (PN) extract plus the mucosal adjuvant cholera toxin (CT) produced PN-specific IgE that correla...

Background Periostin (PN) epithelial and stromal overexpression in tumor pathology has been studied according to tumor growth, angiogenesis, invasiveness, and metastasis, but a limited number of studies address PN in thyroid tumors. Aim Our study aimed to analyze PN expression in different histological variants of PTC and to correlate its expression with the clinicopathological prognostic fac...