The pluripotent potential of embryonic stem cells has often seen them touted as the future of regenerative medicine. The road to any therapeutic success however, must stretch back to teratocarcinoma, the tumour from which pluripotent stem cells (embryonal carcinoma cells) were first derived. This 2011 meeting in Cardiff acted as a historical perspective from which the impact of embryonal carcin...

n engl j med 364;2 nejm.org january 13, 2011 182 stem cells is the standard by which their pluripotent potential is evaluated.1-3 We believe that the intended application of human induced pluripotent stem-cell lines should determine the evaluation method. The issue of pluripotency becomes important for studies of the functional mechanism of reprogramming. However, a reproducible and rapid metho...

Pluripotent stem cells, both human embryonic stem cells (hESC) and human-induced pluripotent stem cells (hiPSC), can give rise to multiple cell types and hence have tremendous potential for regenerative therapies. However, the tumorigenic potential of these cells remains a great concern, as reflected in the formation of teratomas by transplanted pluripotent cells. In clinical practice, most plu...

background: induced pluripotent stem cells (ipscs) can be obtained from autologous cells for therapeutic purposes. so, far, many studies have been done to produce induced pluripotent cells by transferring specific pluripotency genes using different methods. in this study, pluripotency gene expression induced by external stresses was assessed in cord blood mononuclear cells. methods: in this exp...

The genetic reprogramming technology allows one to generate pluripotent stem cells for individual patients. These cells, called induced pluripotent stem cells (iPSCs), can be an unlimited source of specialized cell types for the body. Thus, autologous somatic cell replacement therapy becomes possible, as well as the generation of in vitro cell models for studying the mechanisms of disease patho...

Domesticated ungulate pluripotent embryonic stem (ES) cell lines would be useful for generating precise gene-modified animals. To date, many efforts have been made to establish domesticated ungulate pluripotent ES cells from early embryos without success. Here, we report the generation of porcine-induced pluripotent stem (iPS) cells using drug-inducible expression of defined factors. We showed ...

Embryonic stem cells and induced pluripotent stem cells have the ability to differentiate into various organs and tissues, and are regarded as new tools for the elucidation of disease mechanisms as well as sources for regenerative therapies. However, a method of inducing organ-specific cells from pluripotent stem cells is urgently needed. Although many scientists have been developing methods to...

s session will also be offered on Tuesday morning. Back for its fourth year, the Special Symposium on the Basic Science of Hemostasis and Thrombosis with invited presentations by leaders in the field and simultaneous oral sessions will take place Tuesday morning and afternoon. In a recent Hematologist article, Dr. Bruce Furie discussed the history and rationale for the development of this speci...

Pluripotent stem cells, both human embryonic stem cells (hESC) and human-induced pluripotent stem cells (hiPSC), can give rise to multiple cell types and hence have tremendous potential for regenerative therapies. However, the tumorigenic potential of these cells remains a great concern, as reflected in the formation of teratomas by transplanted pluripotent cells. In clinical practice, most plu...

objective: the exfoliated human deciduous tooth (shed) contain multipotent stem cells that identified to be a population of highly proliferative and clonogenic .these cells are capable of differentiating into a variety of cell types including neural cells, adipocytes, and odontoblasts. material and methods: normal exfoliated human deciduous incisors collected from six- to nine-years-old childre...