نتایج جستجو برای: plga microsphere

تعداد نتایج: 6815  

Journal: :European cells & materials 2008
S Munirah S H Kim B Hi Ruszymah G Khang

Our preliminary results indicated that fibrin and poly(lactic-co-glycolic acid) (PLGA) hybrid scaffold promoted early chondrogenesis of articular cartilage constructs in vitro. The aim of this study was to evaluate in vivo cartilaginous tissue formation by chondrocyte-seeded fibrin/PLGA hybrid scaffolds. PLGA scaffolds were soaked carefully, in chondrocyte-fibrin suspension, and polymerized by ...

2016
Mao Pang Tao Shu Rui-Qiang Chen Chang Liu Lei He Yang Yang Adham Sameer A Bardeesi Cheng-Kai Lin Liang-Ming Zhang Xuan Wang Bin Liu Li-Min Rong

Objective: This study attempted to graft neural precursor cells (NPCs) differentiated from mouse induced pluripotent stem cells (iPSc) with gelatin sponge-electrospun Poly (lactic-co-glycolic acid)-Polyethylene glycol (PLGA/ PEG) nanofibers into transected rat spinal cords and to investigate whether the tissue engineering scaffolds could promote motor functional recovery. Methods: iPSc were dif...

2017
Yong-tao Zhang Jing Niu Zhao Wang Song Liu Jianqun Wu Bin Yu

BACKGROUND To examine the effects of the addition of autologous platelet-rich plasma (PRP) into bilayer poly(lactide-co-glycolide) (PLGA) scaffolds on the reconstruction of osteochondral defects in a rabbit model. MATERIAL AND METHODS Porous PLGA scaffolds were prepared in a bilayered manner to reflect the structure of chondral and subchondral bone. Bone defects, measuring 4 mm in diameter and ...

2012
David A Stout Jennie Yoo Adriana Noemi Santiago-Miranda Thomas J Webster

BACKGROUND Recent advances in nanotechnology (materials with at least one dimension between 1 nm and 100 nm) have led to the use of nanomaterials in numerous medical device applications. Recently, nanomaterials have been used to create innovative biomaterials for cardiovascular applications. Specifically, carbon nanofibers (CNF) embedded in poly(lactic-co-glycolic-acid) (PLGA) have been shown t...

2012
Yiran Ma Xinyi Zhao Jian Li Qi Shen

The aim of this research was to increase the oral bioavailability of daidzein by the formulations of poly(lactic-co-glycolic) acid (PLGA) nanoparticles loaded with daidzein. Amongst the various traditional and novel techniques of preparing daidzein-loaded PLGA nanoparticles, daidzein-loaded phospholipid complexes PLGA nanoparticles and daidzein-loaded cyclodextrin inclusion complexes PLGA nanop...

Journal: :International Journal of Nanomedicine 2006
Soodabeh Davaran Mohammad R Rashidi Behzad Pourabbas Mahin Dadashzadeh Naser Moti Haghshenas

The preparation, properties, and application in adriamycin delivery ofbiocompatible and biodegradable poly(lactide-co-glycolide)-polyethylene glycol (PLGA-PEG) nanoparticles are discussed. PLGA-PEG copolymers were synthesized by ring opening polymerization of the dl-lactide and glycolide in the presence of PEG1000. 1H-NMR and FT-IR spectrum were consistent with the structure of PLGA-PEG copolym...

Journal: :Nanoscale 2013
Yuan Qiu Raghavendra Palankar María Echeverría Nikolay Medvedev Sergio E Moya Mihaela Delcea

Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) incorporating quantum dots (QDs), superparamagnetic iron oxide nanoparticles (SPIONs) and gold (Au) NPs for neutrophil labeling were fabricated via the w/o/w double emulsion method. QDs and SPIONs were entrapped in the PLGA core during emulsification while Au NPs were assembled on top of the PLGA NPs via electrostatic interactions. Transm...

Journal: :Journal of materials science. Materials in medicine 2011
Lihong Lao Yingjun Wang Yang Zhu Yuying Zhang Changyou Gao

Poly(lactide-co-glycolide) (PLGA) nanofibrous composite scaffolds having nano-hydroxyapatite particles (HAp) in the fibers were prepared by electrospinning of PLGA and HAp with an average diameter of 266.6 ± 7.3 nm. Microscopy and spectroscopy characterizations confirmed integration of the crystalline HAp in the scaffolds. Agglomerates gradually appeared and increased on the fiber surface along...

Journal: :Pharmaceutical development and technology 2011
Maliheh Mohaghegh Mohsen Tafaghodi

Potent immunoadjuvants are needed to elicit responses following mucosal delivery. PLGA (poly[D,L-lactic-co-glycolic acid]) nanospheres, Quillaja saponin (QS) and cross-linked dextran microspheres (CDM) as drug delivery and absorption enhancer adjuvants were evaluated. PLGA nanospheres were prepared by solvent evaporation method. Particulate characteristics of nanospheres were studied by optical...

Journal: :Annals of the rheumatic diseases 2005
M Higaki T Ishihara N Izumo M Takatsu Y Mizushima

OBJECTIVE To examine the therapeutic activity of hydrophilic glucocorticoid encapsulated in PLGA nanoparticles, which have shown slow release and are targeted to inflamed joints after intravenous administration, in experimental arthritis models. METHODS Betamethasone sodium phosphate (BSP) encapsulated in PLGA nanoparticles with a size of 100-200 nm (PLGA-nanosteroid) was prepared using a mod...

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