The purpose of this study was to evaluate LC Bead LUMI™ (40-90µm and 70-150µm) in order to determine if their increased resistance to compression influences microsphere penetration and distribution compared to more compressible commercial microspheres. LC Bead LUMI™ 40-90µm and 70-150µm, LC BeadM1® 70-150µm, Embozene™ 40µm and Embozene™ 100µm size and distributions were measured using optical m...

ATTENUATION OF ANTAGONIST-INDUCED IMPAIRMENT IN DOPAMINE RECEPTOR ONTOGENY BY L-PROLYL-L-LEUCYL-GLYCINAMIDE by Mohamad Iqbal Saleh, M.D. It has been shown by others that the prenatal treatment of rats with haloperidol, a dopamine D2 receptor antagonist, leads to a permanent reduction in the number of striatal dopamine D2 receptors in adulthood. Conversely, postnatal treatment of lactating dams ...

OBJECTIVES The aim of this case match study was to compare the outcome of patients with paradoxical low-flow (left ventricular ejection fraction [LVEF] ≥50% but stroke volume index <35 ml/m(2)), low-gradient (mean gradient [MG] <40 mm Hg), a priori severe (aortic valve area [AVA] ≤1.0 cm(2)) aortic stenosis (AS) (PLG-SAS group) with that of patients with a severe AS (AVA ≤1.0 cm(2)) and consist...

The main objective of this study was to investigate biocompatibility and provide in-vivo pharmacological and toxicological evidence for further investigation of the possibility of pH sensitive ion exchange resin microsphere for clinical utilizations. Acute toxicity study and general pharmacological studies were conducted on the pH sensitive ion exchange resin microsphere we prepared. The genera...

Enhanced vascularization is critical to the treatment of ischemic tissues and the engineering of new tissues and organs. We have investigated whether sustained and localized delivery of vascular endothelial growth factor (VEGF) combined with transplantation of human microvascular endothelial cells (HMVECs) can be used to engineer new vascular networks. VEGF was incorporated and released in a su...

Objective: To examine the association of birthweight with indices of glycemia in a population based survey. Methods: 10,788 AusDiab participants were asked to complete a birthweight questionnaire. Fasting plasma glucose (FPG), post load glucose (PLG) and glycosylated haemoglobin (HbA1c) were modelled against birthweight. World Health Organization criteria were used for defining impaired fasting...

Plasmin has been proposed to be an important mediator during inflammation/infection. In this study, by using mice lacking genes for plasminogen, tissue-type plasminogen activator (tPA), and urokinase-type PA (uPA), we have investigated the functional roles of active plasmin in infection and sepsis. Two models were used: an infection model by intravenous injection of 1×10⁷ CFU of S. aureus, and ...

The local environment of neurosecretory cells contains the major components of the plasminogen activation system, including the plasminogen activators, tissue plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), as well as binding sites for t-PA, the receptor for u-PA (uPAR), and also the plasminogen activator inhibitor, PAI-1. Furthermore, these cells express specific ...

Sakata R, +Fujioka H, Inui A, Toyokawa N, Nagura I, Kokubu T, Makino T, Kaneko H, Satake M, Kurosaka M 1 Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, + Department of Orthopaedic Surgery, Hyogo College of Medicine, Nishinomiya, Japan. Department of Tissue Engineering Development, Teijin Technology Innovation Center, TEIJIN Limited, Japan Senior aut...

Tissue engineering strategies that enable nerve regeneration will require methods that can promote and direct neurite extension across the lesion. In this report, we investigate an in vitro combinatorial approach to directed neurite outgrowth using gene delivery from topographically patterned substrates, which can induce expression of neurotrophic factors to promote neurite extension and direct...