background: adipose derived stem cells (ascs) provoke the accumulation and expansion of regulatory t cells, leading to the modulation of immune responses in tumor microenvironment. objective: to assess the effect of tumoral ascs on the trend of regulatory t cells differentiation. methods: peripheral blood naïve cd4+ t cells were co-cultured with ascs derived from breast cancer or normal breast ...

OBJECTIVE To evaluate tensile bond strengths of 2 dentin bonding agents containing solvents on Nd:YAG and Er,Cr:YSGG laser-etched dentin surface. METHOD AND MATERIALS Occlusal enamel of 146 molars was removed, and exposed surfaces were ground with a diamond bur to produce bur-cut dentin surfaces. Of those teeth, 120 were assigned to 3 groups of 40 samples in which dentin was conditioned with ...

Short-term immobilization leads to fatty muscular degeneration, which is associated with various negative health effects. Based on literature showing very high correlations between MRI Dixon fat fraction and Speed-of-Sound (SoS), we hypothesized that can detect short-term-immobilization-induced differences in SoS. Both calves of 10 patients a calf cast one side for mean duration 41 ± 26 days we...

ba ckground: liver cancer is one of the deadly cancers with high prevalence in the east asia. likewise most of diseases, herbs and herbal medicine could be an easy and cost effective tool in prevention and possible cancer treatment. the present study investigated the ability of orthosiphon stamineus benth decoction to protect liver against hepatocellular carcinoma in carcinogenesis-induced anim...

background: mesenchymal stem cells (mscs) are important candidates for msc-based cellular therapy. current paradigm states that mscs support local progenitor cells in damaged tissue through paracrine signaling. therefore, study of paracrine effects and secretome of mscs could lead to the appreciation of mechanisms and molecules associated with the therapeutic effects of these cells. this study ...

conclusions our underlying hypothesis is that recapitulating the three-dimensional early embryonic structure, in order to reproduce better in vitro the three-dimensional morphogenetic-like re-arrangements, would improve cells differentiation, when in vivo transplanted; moreover, it could be used as a simplified cancer disease model and reliable drug evaluation method as well. results the proces...

conclusions our data suggest that preconditioning with 5 μm h2o2 + 0.5% fbs and 10 μm h2o2 + 5% fbs improved cell proliferation and viability. however, the mechanisms related to protective properties of preconditioning and using this strategy in stem cell therapy requires more research. background mesenchymal stem cells (mscs) survival decreased following in vivo injection and its application h...

background: due to increasing clinical demand for adipose tissue, a suitable cell for reconstructive adipose tissue constructs is needed. in this study, we investigated the ability of human endometrial-derived stem cells (enscs) as a new source of mesenchymal stem cells to differentiate into adipocytes. enscs are the abundant and easy available source with no immunological response, for cell re...

background: fusion of dendritic cells (dcs) with melanoma cells could reinforce the antigenicity of tumors as a strategy for the treatment of malignant melanoma. however, the insufficient quantity of dcs and the low fusion efficiency limits the development of such approach. objective: to define the dosage of the stimulating factors as well as the induction condition for the optimal dcs preparat...