Introduction Depressive symptoms are a common feature of schizophrenia (SCH) and define bipolar disorder major depressive (MDD). Their emergence is related to altered neurotransmission at the serotonin receptors potentially dopamine D3 receptors. Objectives The aim this analysis was examine efficacy cariprazine (CAR) in treating SCH, depression (BD) MDD. Methods Clinical trials with randomised,...

Effective early detection of potato late blight (PLB) is an essential aspect cultivation. However, it a challenge to detect at stage in fields with conventional imaging approaches because the lack visual cues displayed canopy level. Hyperspectral can, capture spectral signals from wide range wavelengths also outside wavelengths. In this context, we propose deep learning classification architect...

The aim of the present study was to determine whether the myocardial protective function of Shenmai injection (SM) during ischemia/reperfusion (I/R) is attributable to its regulation of intracellular calcium (Ca2+) and phospholamban (PLB) levels. Cultured neonatal Sprague Dawley rat cardiomyocytes were used to compare the effects of normoxia, total saponins of Panax ginseng (TSPG), ginsenoside ...

The present investigation addresses whether protein expression and function of sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a) and phospholamban (PLB) correlate in failing and nonfailing human myocardium. SERCA2a activity and protein expression, PLB phosphorylation, and the force-frequency relationship (FFR) have been determined in right atrium (RA) and left ventricle (LV) from nonfailing ...

Two genomic clones corresponding to putative pectate lyase genes (plA and plB) were isolated and characterized in strawberry (Fragaria x ananassa cv. Chandler). The corresponding ORFs for the plA and plB genes revealed deduced proteins of 451 and 439 amino acids, respectively, that differ from that of the previously isolated strawberry plC gene. Southern blot analysis has shown that while the p...

In this paper, we present new Boolean matching methods for lookup table (LUT)-based programmable logic blocks (PLBs) and their applications to PLB architecture evaluations and field programmable gate array (FPGA) technology mapping. Our Boolean matching methods, which are based on functional decomposition operations, can characterize functions for complex PLBs consisting of multiple LUTs (possi...

Glucocorticoid-induced leucine zipper (GILZ) is a potent anti-inflammatory protein, the expression of which is mainly induced by glucocorticoids (GCs) in haematopoietic cells. GILZ regulates signal transduction pathways of inflammation and plays a role in cell survival. The objective of this study was to evaluate the expression and mechanisms of action of GILZ in the apoptosis of human neutroph...

Thyroid hormone exerts positive inotropic effects on the heart mediated in part by its regulation of calcium transporter proteins, including sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2), phospholamban (PLB), and Na(+)/Ca(2+) exchanger (NCX). To further understand the potential cardiac chamber-specific effects of thyroid hormone action, we compared the triiodo-L-thyronine (T(3)) responsiv...

Cardioprotection by intermittent high-altitude (IHA) hypoxia against ischemia-reperfusion (I/R) injury is associated with Ca(2+) overload reduction. Phospholamban (PLB) phosphorylation relieves cardiac sarcoplasmic reticulum (SR) Ca(2+)-pump ATPase, a critical regulator in intracellular Ca(2+) cycling, from inhibition. To test the hypothesis that IHA hypoxia increases PLB phosphorylation and th...

Ketzer LA, Arruda AP, Carvalho DP, de Meis L. Cardiac sarcoplasmic reticulum Ca -ATPase: heat production and phospholamban alterations promoted by cold exposure and thyroid hormone. Am J Physiol Heart Circ Physiol 297: H556–H563, 2009. First published June 12, 2009; doi:10.1152/ajpheart.00302.2009.—Shortterm response to cold promotes a small but significant rise in serum T3 in euthyroid rabbits...