Metallic elements, ions and compounds produce varying degrees of toxicity in organisms with which they come into contact. Metal speciation is critical to understanding these adverse effects; the adjectives "heavy" and "toxic" are not helpful in describing the biological properties of individual elements, but detailed chemical structures are. As a broad generalization, the metallic form of an el...

The effects of resveratrol (trans-3,4',5-trihydroxystilbene) on the oxidative stress in blood platelets induced by platinum compounds [cisplatin and selenium-cisplatin conjugate] were studied in vitro. The production of thiobarbituric acid reactive substances (TBARS), the level of conjugate diene, the generation of superoxide anion radicals (O2-*) and other reactive oxygen species (O2-*, H2O2, ...

Using PM-2 DNA and cytotoxicity assay systems, we have studied several second-generation platinum analogs and compared these to the parent compound cis-diamminedichloroplatinum(II). These results indicate that all planar platinum(II) congeners induced similar effects upon interaction with PM-2 DNA, i.e., alteration of the tertiary DNA conformations. The reactivity of the analogs with DNA depend...

A new series of complexes the 2-((1E,2E)-1,2-diphenyl-2-(thiazol-2-ylimino)ethylidene)amino)phenol (DPTYEAP) has been synthesized by reaction ligand with metal chlorides Ni(II), Cu(II), Pt(IV), and AgNO3 in ethanol as a solvent. The was prepared for two steps. In first step, compound (A) reacting 2-aminothiazol benzil ethanol. Another step is preparation from 2-aminophenol. structures its were ...

BACKGROUND For men with advanced castration-resistant prostate cancer (CRPC), several treatment options are available, including androgen receptor (AR) pathway inhibitors (abiraterone acetate, enzalutamide), taxanes (docetaxel, cabazitaxel) and the radionuclide (radium-223). However, cross-resistance is a clinically relevant problem. Platinum compounds have been tested in a number of clinical t...

PURPOSE Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase (PDK), and thus promotes glucose oxidation over glycolysis and induces apoptotic death of tumor cells. The present study investigated the potential of DCA to increase the antitumor effects of platinum- based compounds against a panel of permanent cell lines, including small cell lung cancer (SCLC), ovarian cancer, and Ewing's ...

In search of prospective agents against infectious diseases, 1,1'-bis(diphenylphosphino)ferrocene pyridine-2-thiolato-1-oxide M(ii) hexafluorophosphate compounds [M(mpo)(dppf)](PF6), where M = palladium or platinum, were synthesized and fully characterized in the solid state and in solution using experimental and DFT computational techniques. The compounds are isomorphous and the M(ii) transiti...

Perovskite oxides have emerged as promising alternatives for the supported Platinum group metal catalysts total oxidation of propane and other volatile organic compounds (VOC). Here, we report a surface modification method to improve activity La0.8Sr0.2CoO3 monolithic using diluted oxalic acid etching. The treatment decreases light-off temperatures by 30–40 °C. Experimental DFT investigations r...

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