Beta-thromboglobulin is a platelet specific protein which is released from platelets during the platelet release reaction. The amount of beta-thromboglobulin released during various conditions of in vitro storage, including cryopreservation, was compared. The results suggest the measurement of beta-thromboglobulin is unlikely to be of use as a quality control assay for monitoring the in vitro v...

The thrombogenic potential of atherosclerotic diet-induced coronary atherosclerotic plaques was investigated in normal swine and in bleeder swine with homozygous von Willebrand disease. Fourteen paired normal and bleeder swine were placed on a 1% cholesterol diet for 1 to 16 weeks. Serum cholesterol was elevated in all animals at sacrifice. Foam cell deposits developed in all major epicardial c...

Red blood cells undergo a series of biochemical fluctuations during 35-42-day storage period at 1°C to 6°C. The sodium/potassium pump is immobilised causing a decrease in intracellular potassium with an increase in cytoplasmic sodium levels, glucose levels decline, and acidosis occurs as a result of low pH levels. The frailty of stored erythrocytes triggers the formation of haemoglobin-containi...

Dermatofibrosarcoma protuberans with fibrosarcomatous transformation (DFSP-FS) is a rare variant, higher rates of recurrence and metastasis than DFSP. Detection the collagen type I alpha 1 (COL1A1)–platelet-derived growth factor beta chain (PDGFB) fusion gene useful for diagnosis In this letter, we report case DFSP-FS, focusing on expression COL1A1-PDGFB in lesions. Increased may be associated ...

In a series of important studies Murphy and his colleagues demonstrated that the preparation and storage of platelet-rich plasma and platelet concentrates at 22°C rather than 4°C improved their life span in vivo (Murphy and Gardner, 1969; Murphy, Sayar, and Gardner, 1970). The potential clinical relevance of this finding has been confirmed by Handin and Valeri (1971), and it is likely that this...

In a series of important studies Murphy and his colleagues demonstrated that the preparation and storage of platelet-rich plasma and platelet concentrates at 22°C rather than 4°C improved their life span in vivo (Murphy and Gardner, 1969; Murphy, Sayar, and Gardner, 1970). The potential clinical relevance of this finding has been confirmed by Handin and Valeri (1971), and it is likely that this...