Plasmablastic lymphoma (PBL) is a relatively rare and high grade B cell lymphoma. It often occurs in oral cavity of patients with human immunodeficiency virus (HIV) infection, but it can also be seen in HIV-negative patients. PBL presents a therapeutic challenge to clinicians due to its aggressive clinical feature and high relapse rates. No standard treatment guidelines are formulated. Conventi...

The contribution of Epstein-Barr virus (EBV) to the development of specific types of benign lymphoproliferations and malignant lymphomas has been extensively studied since the discovery of the virus over the last 50 years. The importance and better understanding of the EBV-associated lymphoproliferative disorders (LPD) of B, T or natural killer (NK) cell type has resulted in the recognition of ...

Plasmablastic lymphoma (PBL) is an aggressive subtype of DLBCL, first reported in HIV-infected patients1 and subsequently recognized in the WHO 2008 classification.2 PBL often arises in the oral cavity, but other sites include the nasal cavity, GI tract, skin, bone, and lungs.3-5 PBL mainly affects those with immunodeficiency,3-5 but can affect some immunocompetent individuals.6 Histologically,...

c-MYC is one of the most essential transcriptional factors, regulating a diverse array of cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-MYC is essential in the pathogenesis of a number of B-cell lymphomas, but is rarely reported in T-cell lymphomas. c-MYC dysregulation induces lymphomagenesis by loss of the tight control of c-MYC expression, leading to o...

Post-transplant lymphoproliferative disorders (PTLD) are a serious complication of transplantation with a high mortality. Most PTLD present within the first year of transplantation and are associated with Epstein-Barr virus (EBV) infection. Plasmablastic lymphoma (PBL) is a rare but aggressive disease originally described in patients with HIV, presenting most commonly in the jaw and oral mucosa...

251 Figure (A). Clinical picture shows left orchidectomy with enlarged right testes. (B) Testicular core biopsy showing uniform population of large cells with round nuclei, coarse chromatin and prominent nucleoli (Hematoxylin and Eosin, 40x). (C) Testicular core biopsy showing areas of necrosis and inflammatory infiltrate (Hematoxylin and Eosin, 40x). Testicular biopsy showing plasmablastic lym...

Plasmablastic lymphoma (PBL) is a rare and aggressive variant of diffuse large B cell lymphoma. The prognosis of PBL patients is poor. The majority of patients succumb to a fulminant disease course, with most dying in the first year after diagnosis. The small number of HIV-negative PBL cases reported in the literature to date is composed of single case reports and small case series. Consequentl...