BACKGROUND Ghrelin is a natural growth hormone segretagogue (GHS), involved in the biology of a number of diseases such as lung cancer and prostate cancer. The aim of this study is to assess the relationship existing between ghrelin and testosterone, insulin, and PSA in prostate adenocarcinoma. PATIENTS AND METHODS A patient population and a control population were studied. The former consist...

Ghrelin is an orexigenic peptide predominantly secreted from the stomach and stimulates appetite and growth hormone (GH) release. Studies have provided evidence that ghrelin exercises a wide range of functions, including regulation of food intake and energy metabolism, modulation of cardiovascular function, stimulation of osteoblast proliferation and bone formation and stimulation of neurogenes...

BACKGROUND The role of the orexigenic hormone ghrelin is of major interest in the altered appetite regulation of the elderly. METHODS Basal and postprandial levels of active and total ghrelin were measured in 15 younger (mean age 35.4 years) and 19 older (80.7 years) participants following a carbohydrate-rich test meal. RESULTS Our results showed that older participants felt postprandially ...

results the results indicated that ghrelin significantly decreased thyroid hormone concentrations, whereas estradiol increased these concentrations. the simultaneous injection of ghrelin and estradiol significantly decreased the inhibitory effect of ghrelin on thyroid hormone concentrations (p < 0.05). conclusions according to the results of this study, both ghrelin and estradiol affect the con...

introduction: ghrelin, increases food intake, decreases t3 and t4 concentrations and stimulates insulin release, while leptin reduces food intake and suppresses appetite. considering the importance of thyroid hormones, ghrelin and leptin in body metabolism, the purpose of this study was to investigate the effect of interactions between ghrelin and leptin (injected via icv route) and plasma t3 a...

Objecves Plasmac total ghrelin levels (ie, acylate & unacylated isoformes) are changeable during malnutrion, starvaon regime, exercise bouts, obesity and hyperglycemia condions. Studies have reported increases, decreases or no change in total ghrelin concentraons as a resultsresults of exercise. WalkingSince walking is used as a movement current paern with a different lifestyle condions, especi...

Despite being unable to activate the cognate ghrelin receptor (GHS-R), unacylated ghrelin (UAG) possesses a unique activity spectrum that includes promoting bone marrow adipogenesis. Since a receptor mediating this action has not been identified, we re-appraised the potential interaction of UAG with GHS-R in the regulation of bone marrow adiposity. Surprisingly, the adipogenic effects of intra-...

The most unique feature of ghrelin is the acyl-modification of a hydroxyl group of the Ser3 in the N-terminus. The Ser3 is commonly modified by n-octanoic acid in vertebrates being needed for its biological effects, at least in terms of feeding. Therefore, a critical question regarding the role of ghrelin was to characterize the mechanism involved in its acylation. The acyltransferase that cata...

Introduction: ghrelin is a potent orexigenic agent in rodents and humans. Some studies have shown that ghrelin participates in the adaptive response to weight loss and plasma concentration of ghrelin rises with dieting. On the other hand, weight loss and fasting is accompanied by increased levels of epinephrine and cortisol. In this study, we investigated the effects of epinephrine and corti...

The propensity of diets of different composition to promote obesity is a current topic in feline medicine. The effects of three meals with different protein:fat ratios on hormones (insulin, acylated ghrelin and amylin) involved in the control of food intake and glucose metabolism were compared. Five lean (two females and three males, 28.6 (sd 3.4) % body fat mass (BFM), mean body weight (BW) 45...