Recent studies indicated that the Zika virus genome could be detected in the amniotic fluid and the fetal brain, which confirms that the virus can cross the placental barrier. Secretory autophagy or exosome pathways may participate in this virus transfer. Autophagy modulators regulate autophagosome formation or membrane fusion with lysosomal vesicles and therefore inhibit viral nucleocapsid rel...

BACKGROUND Transplacental transmission of human cytomegalovirus (CMV) can result in congenital malformations, although details on the mechanisms of transmission and the location of CMV in infected placentae need to be described.METHODS. Placental tissue from term (third trimester) deliveries was screened for CMV infection by polymerase chain reaction (PCR), in situ PCR (IS-PCR), and IS reverse-...

The placenta is a distinctive organ, which facilitates the supply of oxygen and nutrients to the fetus through placental microcirculation. Placenta potentially plays a key role in the etiology of developmental programming through its impact on nutrient transfer. Placental transport efficiency depends on a variety of parameters, including surface area for exchange, thickness of the placental mem...

INTRODUCTION Weight of placenta has long been associated with fetal growth and perinatal well-being. Low placental weight (standardized for sex gestational age) is more common among stillbirths whereas high neonatal death, serious morbidity, low 5-min Apgar score, respiratory morbidity. believed to reflect an inadequate surface area nutrient gas exchange, leading compromise. However, it also pro...

Background: Currently, frozen embryo transfers contribute an increasing rate of births from assisted reproductive technologies such as in vitro fertilization (IVF). However, very few studies evaluated the neonatal outcomes from frozen embryo transfer. This study aimed to investigate and compare the neonatal outcomes from frozen embryo transfer versus fresh embryo transfers. Materials and Method...

normal 0 false false false en-us x-none ar-sa background: placental abruption is one of the most common causes of bleeding during pregnancy. multiple factors are known to be associated with increase of risk of placental abruption such as alcohol, cocaine use and cigarette smoking. the objective of this study was to identify risk factors for placental abruption in an iranian women population. ma...

UNLABELLED Previous work in our laboratory demonstrated that over-expression of human insulin-like growth factor -1 (hIGF-1) in the placenta corrects fetal weight deficits in mouse, rat, and rabbit models of intrauterine growth restriction without changes in placental weight. The underlying mechanisms of this effect have not been elucidated. To investigate the effect of intra-placental IGF-1 ov...

The genes coding for human (h) chorionic somatomammotropin (CS), hCS-A and hCS-B, and placental growth hormone (GH-V), hGH-V, are located at a single locus on chromosome 17. Efficient expression of these placental genes has been linked to local regulatory (5' P and 3' enhancer) sequences and a remote locus control region (LCR), in part, through gene transfer in placental and nonplacental tumor ...

Placental transfer of the HIV protease inhibitor darunavir was investigated in 5 term human cotyledons perfused with darunavir (1,000 ng/ml) in the maternal to fetal direction. The mean (± the standard deviation [SD]) fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 30 to 90 min) was 15.0%±2.1%, and the mean (±SD) clearance index (darunavir FTR/antipyrine FTR) was 40...

background & aim: occupational exposures can cause problems such as reproductive system disorders; however, the effects of some exposures, such as psychological stress, have not been investigated yet. this study aims to investigate the effects of women’s psychological stress on obstetric disorders. methods:this historical cohort study was conducted on 1400 working women in mashhad, iran. data c...