نتایج جستجو برای: pla2

تعداد نتایج: 1363  

2010
Gennaro Galasso Gaetano Santulli Federico Piscione Roberta De Rosa Valentina Trimarco Raffaele Piccolo Salvatore Cassese Guido Iaccarino Bruno Trimarco Massimo Chiariello

BACKGROUND The clinical impact of PlA2 polymorphism has been investigated in several diseases, but the definition of its specific role on thrombotic cardiovascular complications has been challenging. We aimed to explore the effect of PlA2 polymorphism on outcome in patients with atherosclerosis. METHODS We studied 400 consecutive patients with coronary artery disease (CAD) undergoing percutan...

Journal: :The Biochemical journal 1996
B S Vishwanath W Eichenberger F J Frey B M Frey

Several structurally related plant lipids were isolated and their effect was assessed on the enzyme activity of group I (pancreatic and Naja mocambique venom) and group II (Crotalus atrox venom) phospholipase A2 (PLA2) enzymes, with labelled Escherichia coli as an enzyme substrate. The neutral monogalactosyldiacylglycerol (MGDG) and negatively charged diacylglyceryl alpha-D-glucuronide (DGGA) d...

Journal: :The Journal of pharmacology and experimental therapeutics 1998
S Abu-Raya E Bloch-Shilderman E Shohami V Trembovler Y Shai J Weidenfeld S Yedgar Y Gutman P Lazarovici

The effect of Pardaxin, a neurotoxin that induces neurotransmitter release from neurons, on the arachidonic acid (AA) cascade was studied in PC12 cells. Both native and the synthetic Pardaxin selectively stimulated phospholipase A2 (PLA2) activity (measured by [3H]AA release) in the presence as well as in the absence of extracellular calcium. Pardaxin-stimulated PLA2 activity was also evident i...

Journal: :Archives of internal medicine 2005
Christie M Ballantyne Ron C Hoogeveen Heejung Bang Josef Coresh Aaron R Folsom Lloyd E Chambless Merle Myerson Kenneth K Wu A Richey Sharrett Eric Boerwinkle

BACKGROUND Measurement of inflammatory markers has been reported to identify individuals at increased risk for ischemic stroke. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a proinflammatory enzyme secreted by macrophages. We assessed Lp-PLA2 and C-reactive protein (CRP) levels along with traditional risk factors to examine their relation to ischemic stroke. METHODS A proportional haz...

Journal: :Clinical chemistry 2009
Joseph P McConnell Allan S Jaffe

Current treatment strategies have resulted in significant reductions in morbidity and mortality associated with cardiovascular disease; however, significant residual risk remains. As an example, in the PROVE IT– TIMI 22 trial (Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22), 22.4% of patients experienced an adverse event despite achieving a...

Journal: :Journal of neurochemistry 1993
M V Catania Z Hollingsworth J B Penney A B Young

Exogenous phospholipases have been used extensively as tools to study the role of membrane lipids in receptor mechanisms. We used in vitro quantitative autoradiography to evaluate the effect of phospholipase A2 (PLA2) on N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptors in rat brain. PLA2 pretreatment induced a significant increase in alpha-[3H]amino-3-hydroxy-5-methyl-isoxazole-4-pr...

Journal: :Archives of insect biochemistry and physiology 2005
Youngjin Park A R Nor Aliza David Stanley

We report on a secretory phospholipase A2 (sPLA2) associated with membrane-enriched fractions prepared from hemocytes of the tobacco hornworms, Manduca sexta. Virtually no PLA2 activity was detected in serum of immunologically naive or bacterially challenged hornworms. PLA2 activity was detected in cytosolic and membrane-enriched fractions prepared from hemocytes. PLA2 activity in the cytosolic...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2016
Parveen K Garg Alice M Arnold Karen D Hinckley Stukovsky Carol Koro Nancy S Jenny Kenneth J Mukamal Michael H Criqui Curt D Furberg Anne B Newman Mary Cushman

OBJECTIVE Although prior studies report a relationship between elevated lipoprotein-associated phospholipase A2 (Lp-PLA2) and incident cardiovascular disease, the prospective association of Lp-PLA2 with incident peripheral arterial disease (PAD) has not been studied. We investigated the association between Lp-PLA2 mass and activity and the risk of developing clinical PAD and low ankle-brachial ...

Journal: :The Journal of biological chemistry 1994
K P Chepenik A Diaz S A Jimenez

Confluent, primary cultures of mouse embryo palate mesenchyme (MEPM) cells are refractory to activation of phospholipase A2 (PLA2) by the calcium ionophore A23187. However, treatment of these cultures with epidermal growth factor (EGF) permits the cells to activate PLA2 in response to A23187. We have developed this finding by exploring molecular mechanisms by which growth factors modulate mobil...

2011
Eman AL-Shawaf Sarka Tumova Jacqueline Naylor Yasser Majeed Jing Li David J. Beech

The Transient Receptor Potential Canonical 5 (TRPC5) protein forms calcium-permeable cationic channels that are stimulated by G protein-coupled receptor agonists. The signaling pathways of such agonist effects are poorly understood. Here we investigated the potential for involvement of lysophosphatidylcholine (LPC) and arachidonic acid generated by group 6 (GVI) phospholipase A2 (PLA2) enzymes,...

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