نتایج جستجو برای: pkd2

تعداد نتایج: 596  

2016
Daniel T Grimes Jennifer L Keynton Maria T Buenavista Xingjian Jin Saloni H Patel Shinohara Kyosuke Jennifer Vibert Debbie J Williams Hiroshi Hamada Rohanah Hussain Surya M Nauli Dominic P Norris

During mammalian development, left-right (L-R) asymmetry is established by a cilia-driven leftward fluid flow within a midline embryonic cavity called the node. This 'nodal flow' is detected by peripherally-located crown cells that each assemble a primary cilium which contain the putative Ca2+ channel PKD2. The interaction of flow and crown cell cilia promotes left side-specific expression of N...

Journal: :Journal of medical genetics 1995
S E Pound S Thomas A Snarey A M Macnicol M L Watson P M Pignatelli A M Frischauf P C Harris A F Wright

Haplotype analysis was performed in 35 autosomal dominant polycystic kidney disease (ADPKD) families typed with 13 markers close to the PKD1 locus. The identification of recombinants close to the PKD1 gene on chromosome 16p indicates that PKD1 lies between CMM65 distally and 26-6 proximally. In addition, three unlinked (PKD2) families and two families with potential new mutation were identified.

Journal: :Journal of Cell Science 2022

ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping early-career researchers promote themselves alongside their papers. Debatrayee Sinha author on ‘ Fission yeast polycystin Pkd2p promotes cell size expansion and antagonizes Hippo-related SIN pathway’, JCS. PhD student lab Qian Chen at The University Toledo, OH, USA,...

Journal: :Nephrology Dialysis Transplantation 2009
Xiaofang Wang Peter C. Harris Stefan Somlo Daniel Batlle Vicente E. Torres

BACKGROUND Antagonists of relevant Gs protein-coupled and agonists of relevant Gi protein-coupled receptors lower renal cAMP and inhibit growth of renal cysts in animal models of human ARPKD (PCK rat) and/or ADPKD (Pkd2(-/WS25) mouse). A calcium-sensing receptor (CaR) is expressed in various tubular segments and couples to Gq, thereby activating phospholipase Cgamma, InsP3 generation and calciu...

Journal: :Journal of the American Society of Nephrology : JASN 2007
Sandro Rossetti Mark B Consugar Arlene B Chapman Vicente E Torres Lisa M Guay-Woodford Jared J Grantham William M Bennett Catherine M Meyers Denise L Walker Kyongtae Bae Qin Jean Zhang Paul A Thompson J Philip Miller Peter C Harris

Mutation-based molecular diagnostics of autosomal dominant polycystic kidney disease (ADPKD) is complicated by genetic and allelic heterogeneity, large multi-exon genes, duplication of PKD1, and a high level of unclassified variants (UCV). Present mutation detection levels are 60 to 70%, and PKD1 and PKD2 UCV have not been systematically classified. This study analyzed the uniquely characterize...

Journal: :Molecular cancer therapeutics 2014
Ning Wei Edward Chu Peter Wipf John C Schmitz

Protein kinase D (PKD) signaling plays a critical role in the regulation of DNA synthesis, proliferation, cell survival, adhesion, invasion/migration, motility, and angiogenesis. To date, relatively little is known about the potential role of PKD in the development and/or progression of human colorectal cancer. We evaluated the expression of different PKD isoforms in colorectal cancer and inves...

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