نتایج جستجو برای: piperine
تعداد نتایج: 665 فیلتر نتایج به سال:
Floating tablets of Marichyadi Vati were developed with an aim to prolong its gastric residence time and increase the bioavailability of drug. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The tablets were prepared by wet granulation technique, using HPMC E50...
A crystalline compound [{(1,5-(1,3)benzodioxol-5yl)-1-oxo-2,4pentadienyl}-piperidine] and few sesquiterpenes ( Caryophyllene, β–bisabolene, δ –Cadinene, Elemol, (-)Cedreanol, αEudesmol ) were obtained from the toluene extract of dried fruits of Piper nigrum. This is for the first time piperine has been extracted from the cold toluene extract of Piper nigrum along with few other sesquiterpenes. ...
Animal studies were conducted to evaluate the influence of dietary spice compounds, piperine, capsaicin and ginger, on the absorption of orally administered β-carotene and its conversion to vitamin A. In rats maintained on these spice-containing diets for 8 weeks, concentrations of β-carotene and retinol were determined in the serum, liver and intestine 4 h after a single oral administration of...
Research conducted to meet the needs of standard compounds in practical and research activities. The use improves quality a study. Piperine is main secondary metabolite compound alkaloid group contained Black PepperÃÂ Piper nigrumÃÂ L. isolation method used reflux recrystallization methods. process absorbing piperine with diethyl ether solvent will help break down cell walls absorb optimally....
Human Cytochrome P450 2J2 (CYP2J2) as an important metabolic enzyme, plays a crucial role in metabolism of polyunsaturated fatty acids (PUFAs). Elevated levels CYP2J2 have been associated with various types cancer, and therefore it serves potential drug target. Herein, using high-throughput screening approach based on enzymic activity CYP2J2, we rapidly effectively identified novel natural inhi...
The flagellate Trypanosoma brucei causes sleeping sickness in humans and nagana in animals. Only a few drugs are registered to treat trypanosomiasis, but those drugs show severe side effects. Also, because some pathogen strains have become resistant, new strategies are urgently needed to combat this parasitic disease. An underexplored possibility is the application of combinations of several tr...
OBJECTIVE To study the efficacy and tolerability of Risorine Capsule (A fixed dose combination of Rifampicin 200 mg + INH 300 mg + Piperine 10 mg) therapy in the treatment of drug-susceptible pulmonary tuberculosis patients who developed GI intolerance with standard WHO anti TB regimen. METHODS 33 patients with pulmonary tuberculosis were treated with one Risorine kit, daily consisting of one...
Piper longum L. is a well-known traditional antihyperlipidemic medicine in China, containing medicinal constituents of piperine, pipernonaline and piperlonguminine in its fruit. However, the antitumor properties of these constituents have not yet been studied. We found that potassium piperate (GBK), a derivative of piperine, inhibited proliferation of cancer cells. GBK selectively inhibited the...
New Delhi Metallo-β-lactamase 1 (NDM-1) is a monomeric, plasmid-encoded enzyme that can hydrolyze β-lactam antibiotics over a wide range. Presence of this enzyme renders the host bacteria immune to carbapenems, the so-called last resort drugs, as reported in Klebsiella pneumonia, Escherichia coli and Acenetobacter baumanii. Multi-drug resistance of nosocomial pathogens as above possess a seriou...
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