Piperlongumine is an alkaloid compound extracted from Piper longum L. It is a chemical substance with various pharmacological effects and medicinal value, including anti-tumor, lipid metabolism regulatory, antiplatelet aggregation and analgesic properties. The present study aimed to understand whether piperlongumine induces the apoptosis and autophagy of leukemic cells, and to identify the mech...

Objective: The development of modern dosage form such as lozenges associated with an extended period of local remedy with beneficial therapeutic effect was the objective of this study. The polyherbal extract based lozenges include Viola odorata L, Cordialatifolia L, Menthapiperita L., Adhatodavasica, Glycyrrhizaglabra, Piper longum, Hyssopusofficinalis, Alpiniagalangal which is envisioned for c...

Background: Despite the fact that liver steatosis is a very frequent condition mainly due to alcohol comsumption and metabolic syndrome, yet there is no consensus regarding appropriate therapy. Aim and study design: Open label nonrandom study in order to assess efficiency of liver protective phytoproducts in patients with nonalcoholic steatohepatitis(NASH) Patients and methods: 30 patients , 11...

The concept of bioavailability enhancer is new to the modern system of medicine. Basically, this concept originated in Ayurveda and being used in this system of medicine since centuries. Bio-enhancers augment the bioavailability or biological activity of drugs when co-administered with principal drug at low doses. Ayurveda is using several drugs such as Piper longum Linn., Zingiber officinale R...

Piperine, [1-[5-[1,3-benzodioxol-5-yl]-1-oxo-2,4, pentadienyl] piperidine], is a pungent alkaloid present in Piper nigrum Linn, and P. longum Linn. It is shown to enhance the bioavailability of various structurally and therapeutically diverse drugs. A concise mechanism responsible for its bioavailability enhancing action is poorly understood. This study is an effort to understand the absorption...

Activit, a herbomineral formulation, containing extracts derived from Mucuna pruriens, Withania somnifera, Argyreia speciosa, Centella asiatica, Tribulus terrestris, Asparagus racemosus, Piper longum, Anacyclus pyrethrum, Nux vomica, Tinospora cordifolia and Shring bhasma, was studied for its protective effect against gastric lesions induced by ethanol and pylorus-ligation. The formulation was ...

Characteristic ultrastructural changes were observed when protoscoleces of hydatid cysts Echinococcus granulosus was treated with extract of endophytic fungi Eupenicillium and Chaetomium sp. isolated from Azadirachta indica and Piper longum plants respectively. A sharp decrease in viability of protoscoleces was observed after 6 h of incubation with fungal extracts. The ultrastructural changes i...

This article describes free radical-scavenging activities of extracts of several plants harvested in Sri Lanka through the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. These plants have traditionally been used in the indigenous systems of medicine in Sri Lanka, such as Ayurveda, as described below. (English name, "local name in Sri Lanka," (scientific name)). bougainvillea plant, "bouganvilla," ...

BACKGROUND Piperlongumine, a component of Piper longum fruit, is considered as a treatment for malignancy. It is effective by inducing apoptosis. Mechanisms involved in the apoptotic action of piperlongumine include oxidative stress and activation of p38 kinase. In analogy to apoptosis of nucleated cells, erythrocytes may undergo eryptosis, the suicidal death of erythrocytes characterized by ce...

tuberculosis, M. bovis, M. africanum and others, known collectively as the M. tuberculosis complex (MTC) [1]. M. tuberculosis is responsible for more human mortality than any other single microbial species [2]. According to estimates by World Health Organization (WHO), almost 9 million new cases and 1.4 million TB deaths occurred in 2011 [3]. Although there are effective anti-tubercular agents,...