The control of genotoxic impurities (GTIs) is a crucial activity that is performed for any new chemical entity intended for clinical use. A key element of this is the quality risk assessment. This article seeks to examine the primary components of such a strategy, focusing specifically on the effective use of in silico assessment tools to augment this process, in particular the calculation of t...

This study combined the probiotic properties of Lacticaseibacillus casei AP with prebiotic oats to improve kefir products. AP, oat milk, or both were added goat milk kefir. Physicochemical properties, microbiological evaluation, and sensory evaluation done over course 14 days. The result showed that adding together had positive (non-opposing) effects on physicochemical, microbiological, product...

Recent advancement in the pattern recognition field stimulates enormous interest in Protein Fold Recognition (PFR). PFR is considered as a crucial step towards protein structure prediction and drug design. Despite all the recent achievements, the PFR still remains as an unsolved issue in biological science and its prediction accuracy still remains unsatisfactory. Furthermore, the impact of usin...

This critical review examines in vitro and in vivo evidence for the influence of engineered nanomaterial (ENM) physicochemical properties on their distribution into, and effects on, the nervous system. Nervous system applications of ENMs; exposure routes and potential for uptake; the nervous system and its barriers to ENM uptake; and the mechanisms of uptake into the nervous system and overcomi...

Physicochemical properties (partition and diffusion coefficients) involved in the mobility and release of salt and aroma compounds in model cheeses were determined in this study. The values of NaCl water/product partition coefficients highlighted interactions between proteins and NaCl. However, these interactions were not modified by the product composition or structure. On the contrary, model ...

Cytotoxicity of 5 phenol derivatives (phenol, catechol, resorcinol, hydroquinone and phloroglucinol) was tested using a mouse 3T3 fibroblast cell line. Its relationships with structural and physicochemical properties were investigated. Linear regression analysis and Pearson's correlation coefficient were used to characterise the relationship between cytotoxicity (expressed by IC(50) values) and...

The viscosities of eight melt compositions in the System albite-H20-F20_1 have been determined at high pressure and temperature. Measurements were performed using the falling sphere method at 1000-1600°C and 2.5 to 22.5 kbar. Fluorine and water strongly decrease the viscosity of albite melt at all pressures and temperatures investigated. The viscosity of a fluorine-bearing albitic melt decrease...

Ando T, Hasegawa Y and Uchiyama M (1986) Separation of lepidopterous sex-pheromones by reversed-phase thin-layer chromatography and high-performance liquid-chromatography. Agricultural and Biological Chemistry 50: 2935. Bertsch WS, Hara S, Kaiser RE and Zlatkis A (eds) (1987) Instrumental HPTLC. Heidelberg: HuK tig. Cammaerts-Tricot M-C, Morgan ED and Tyler RC (1977) Isolation of the trail pher...