it is well known that the chemical behavior of a compound is dependent upon the structure of itsmolecules. quantitative structure – activity relationship (qsar) studies and quantitative structure –property relationship (qspr) studies are active areas of chemical research that focus on the nature ofthis dependency. topological indices are the numerical value associated with chemical constitution...

Hydrothermal features in Portugal have been used since ancient times for therapeutic purposes that are mainly distributed in north and central region, being Beira Interior, located in central region, is characterized by eight spas. As for Portuguese thermo-mineral waters there are scarce studies about the characterization of its relation with the beneficial effects on human health. In last deca...