Adsorption onto silica-based high surface area carriers is a long known method of improvement drug dissolution rate, which has been described in early 1970s [1]. Porous silica has many silanol groups on its surface and can be used as pharmaceutical excipient, since it is regarded nontoxic after oral application. Due to its porous structure and large specific surface area, porous silica has a gr...

The physical stability of sonicated arsonoliposomes in the absence and presence of Ca(2+) ions is evaluated. Cholesterol-containing arsonoliposomes composed of arsonolipids [having different acyl chains (C(12)-C(18))], or mixtures of arsonolipids with phospholipids (phosphatidylcholine or distearoyl-phosphatidylcholine) were prepared, and physical stability was evaluated in the absence and pres...

Visual estimation of object stability is an ecologically important judgment that allows observers to predict the physical behavior of objects. A natural method that has been used in previous work to measure perceived object stability is the estimation of perceived “critical angle” – the angle at which an object appears equally likely to fall over versus return to its upright stable position. Fo...

Frames which are tight might be considered optimally conditioned in the sense of their numerical stability. This leads to the question of perfect preconditioning of frames, i.e., modification of a given frame to generate a tight frame. In this paper, we analyze prefect preconditioning of frames by a diagonal operator. We derive various characterizations of functional analytic and geometric type...

Painlevé paradox occurs in rigid-body dynamics of mechanical systems with frictional contacts at configurations where the instantaneous solution is either indeterminate or inconsistent. Dynamic jamming is a scenario where the solution starts with consistent slippage and then converges in finite time to a configuration of inconsistency while the contact force grows unbounded. The goal of this pa...

We present a simple shape-from-shading algorithm that uses two shading images. This enables us to estimate more accurate shapes of objects without any special constraints or conditions than the existing photometric stereo algorithms. The Jacobi’s iterative method is applied to the difference between the image and the reflectance function represented as a function of three depth parameters for e...

References 1. Barkhausen J et al. Whole-body MR imaging in 30 seconds with real-time true FISP and a continuously rolling table platform: feasibility study. Radiology.2001;220:252-6. 2. Zenge MO et al. Whole-body magnetic resonance imaging featuring moving table continuous data acquisition with high-precision position feedback. Magn Res Med 2005;54:707-711. Whole-body MR imaging with continuous...

Cyber-Physical Systems (CPS) consist of distributed computation interconnected by computer networks that monitor and control switched physical entities interconnected by physical infrastructures. Finding a common semantic among these diverse components that facilitates system synthesis, verification, and monitoring is a significant challenge of a CPS research program. In the emerging smart grid...

The effects of excipient crystallinity and water content on the physical stability of salmon calcitonin (sCT) in a spray-dried powder for inhalation have been investigated. sCT was dissolved in water with and without mannitol and then spray dried using a Büchi 190 spray dryer. The spray dried powders were stored for 5 days at 0, 29, 51, 58, 69, and 84% relative humidity at ambient temperature. ...