The brain mechanisms involved in processing another's physical pain have been extensively studied in recent years. The link between understanding others' physical pain and emotional suffering is less well understood. Using whole brain analysis and two separate functional localizers, we characterized the neural response profiles of narrative scenarios involving physical pain (PP), and scenarios ...

Pain, whether caused by physical injury or social rejection, is an inevitable part of life. These two types of pain-physical and social-may rely on some of the same behavioral and neural mechanisms that register pain-related affect. To the extent that these pain processes overlap, acetaminophen, a physical pain suppressant that acts through central (rather than peripheral) neural mechanisms, ma...

BACKGROUND AND OBJECTIVES To test the hypothesis that self-reported physical functioning is more influenced by pain than performance-based physical functioning. METHODS 163 knee-osteoarthritis patients completed the performance-based DynaPort KneeTest (DPKT), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and SF-36 (self-report measures of pain and physical functionin...

Numerous languages characterize 'social pain', the feelings resulting from social estrangement, with words typically reserved for describing physical pain ('broken heart', 'broken bones') and perhaps for good reason. It has been suggested that, in mammalian species, the social-attachment system borrowed the computations of the pain system to prevent the potentially harmful consequences of socia...

oxycodone is widely used to alleviate moderate-to severe acute pain, it is an effective analgesic for many types of pain, and is especially useful for paroxysmal spontaneous pain, steady pain, allodynia associated with postherpetic neuralgia, and it is also increasingly used in the management of cancer-related and chronic pain, oxycodone has been found to improve the quality of life of patients...

disturbances in fibromyalgia syndrome: relationship to pain and depression. Sleep disturbance is a widely reported and debilitating concomitant of fibromyalgia syndrome (FMS) and plays a pivotal role in exacerbating patients reporting of symptoms. Bigatti and colleagues report a longitudinal study that examined self-reported sleep, pain, depression and physical functioning at baseline in FMS pa...

BACKGROUND Chronic low back pain is a worldwide burden that is not being abated with our current knowledge and treatment of the condition. The fear-avoidance model is used to explain the relationship between pain and disability in patients with chronic low back pain. However there are gaps in empirical support for pathways proposed within this model, and no evidence exists as to whether physica...

Previous studies have shown that observing another's pain can evoke other-oriented emotions, which instigate empathic concern for another's needs. It is not clear whether experiencing first-hand physical pain may also evoke other-oriented emotion and thus influence people's moral judgment. Based on the embodied simulation literature and neuroimaging evidence, the present research tested the ide...