A simple, precise, specific, and accurate reverse phase HPLC method has been developed for the determination of pregabalin in capsule dosage form. The chromatography was set on Hypersil BDS, C8, 150×4.6 mm, 5 μm column using photodiode array detector. The mobile phase consisting of phosphate buffer pH 6.9 and acetonitrile in the ratio of 95:05 with flow rate of 1 ml/min. The method was validate...

A reverse phase High pressure liquid chromatography (HPLC) method to determine puerarin in Pueraria tuberose was developed and described. The method involves separation of active compound using mobile phase consisting of acetonitrile: water: orthophosporic acid in the ratio of 32:67:01 and detecting the chromatogram at 280 nm using photodiode array detector. The sensitivity of the method was ob...

A monolithic capillary electrophoresis system with integrated on-chip fluorescence detector has been microfabricated on a silicon substrate. Photodiodes in the silicon substrate measure fluorescence emitted from eluting molecules. The device incorporates an on-chip thin-film interference filter that prevents excitation light from inhibiting the fluorescence detection. A transparent AZO conducti...

This paper presents a highly sensitive photo-detector array deposited on a glass substrate with an integrated optical filter. The active element is a vertically integrated hydrogenated amorphous silicon photodiode featuring a dark current of less than 1e-10 A/cm for -3V bias voltage and a maximal quantum efficiency of 80% near 580 nm. The prototype was encapsulated and tested optically. It has ...

This paper presents a low noise CMOS image sensor (CIS) using 10/12 bit configurable column-parallel single slope ADCs (SS-ADCs) and digital correlated multiple sampling (CMS). The sensor used is a conventional 4T active pixel with pinned-photodiode as detector. The test sensor has been fabricated in 0.18 μm CMOS image sensor process from TSMC. The ADC nonlinearity measurement result shows tota...

By specifically targeting sponges likely to contain oroidin derivatives, we have, for the first time, identified Australian sponges that contain sceptrin (2) and related compounds. Using a simple extraction technique and HPLC (with a photodiode array detector) in combination with LC-MS and MS-MS we have been able to quickly identify known compounds and flag the presence of some new compounds in...

We present a charge integration photon detector (CIPD) that enables the efficient measurement of photon number states at the telecom-fiber wavelengths with a quantum efficiency of 80% and a resolution less than 0.5 electrons at 1 Hz sampling. The CIPD consists of an InGaAs PIN photodiode and a GaAs JFET in a charge integration amplifier, which is cooled to 4.2 K to reduce thermal noise and leak...

A new automated, qualitative screening HPLC method for the identification of basic compounds in urine has been established. A 1-ml volume of urine was automatedly extracted online and separated on two coupled strong cation-exchange columns under isocratic conditions. The use of the photodiode-array detector (DAD, λ=190-370 nm) gave access to a library of more than 2600 toxicologically relevant ...

Demodulation of intensity noise in the optical heterodyne detector is analyzed for application in interferometric gravitational-wave detectors. The correlation function and the power spectral density of the demodulated intensity noise are derived, taking into account the effect of bandpass filtering at the photodiode and an arbitrary demodulation waveform. The analysis includes demodulation of ...

We investigate the performance of separate absorption multiplication InGaAs/InP avalanche photodiodes as single-photon detectors for 1.3- and 1.55-mum wavelengths. First we study afterpulses and choose experimental conditions to limit this effect. Then we compare the InGaAs/InP detector with a germanium avalanche photodiode; the former shows a lower dark-count rate. The effect of operating temp...