نتایج جستجو برای: phospholipase d pld

تعداد نتایج: 596477  

2015
Nataliya A. Babenko Vitalina S. Kharchenko

Background. The role of phospholipase D (PLD) as a positive modulator of glucose uptake activation by insulin in muscle and adipose cells has been demonstrated. The role of PLD in the regulation of glucose metabolism by insulin in the primary hepatocytes has been determined in this study. Methods. For this purpose, we studied effects of inhibitors of PLD on glucose uptake and glycogen synthesis...

Journal: :Oncology reports 2007
Masaru Saito Manabu Iwadate Masashi Higashimoto Koichiro Ono Yuji Takebayashi Seiichi Takenoshita

Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. PA acts as a second messenger in cell proliferation; therefore PLD is believed to play an important role in carcinogenesis. PLD activity has been reported to be elevated in human breast, gastric, renal cell and colorectal carcinomas, compared with adjacent non-neoplastic ti...

Journal: :The Biochemical journal 2005
Soha Zouwail Trevor R Pettitt Stephen K Dove Margarita V Chibalina Dale J Powner Lee Haynes Michael J O Wakelam Robert H Insall

PLD (phospholipase D) activity catalyses the generation of the lipid messenger phosphatidic acid, which has been implicated in a number of cellular processes, particularly the regulation of membrane traffic. In the present study, we report that disruption of PLD signalling causes unexpectedly profound effects on the actin-based motility of Dictyostelium. Cells in which PLD activity is inhibited...

Journal: :The Biochemical journal 1997
T W Lee S Cotecchia G Milligan

The alpha1-adrenergic agonist phenylephrine stimulated phospholipase D (PLD) activity in Rat 1 fibroblasts transfected to express either the wild-type hamster alpha1B-adrenoceptor or a constitutively active mutant (CAM) form of this receptor. The EC50 for agonist stimulation of PLD activity was substantially lower at the CAM receptor than at the wild-type receptor as previously noted for phenyl...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2006
Joaquin Benitez-Rajal Maria-Jose Lorite Alastair D Burt Christopher P Day Michael G Thompson

We have previously provided evidence suggesting that phosphatidic acid, possibly derived from the hydrolysis of phosphatidylcholine by phospholipase D (PLD), is involved in platelet-derived growth factor (PDGF)-mediated increases in extracellular signal-regulated kinase (ERK) activity and DNA synthesis in rat hepatic stellate cells (HSC), the primary fibrogenic cells of the liver. A recent stud...

2010
Elena Madrid Purificación Corchete

The flavonolignan silymarin is released to the extracellular medium of Silybum marianum cultures and its production can be stimulated by the elicitor methyljasmonate (MeJA). The sequence of the signalling processes leading to this response is unknown at present. It is reported in this work that MeJA increased the activity of the enzyme phospholipase D (PLD). Treatment with mastoparan (Mst), a P...

Journal: :Current Biology 1998
Marc CM van Dijk Friso Postma Henk Hilkmann Kees Jalink Wim J van Blitterswijk Wouter H. Moolenaar

BACKGROUND Phospholipase D (PLD) hydrolyzes phospholipids to generate phosphatidic acid (PA) and a free headgroup. PLDs occur as both intracellular and secreted forms; the latter can act as potent virulence factors. Exogenous PLD has growth-factor-like properties, in that it induces proto-oncogene transcription, mitogenesis and cytoskeletal changes in target cells. The underlying mechanism is u...

Journal: :Plant, cell & environment 2009
Bastiaan O R Bargmann Ana M Laxalt Bas ter Riet Christa Testerink Emmanuelle Merquiol Alina Mosblech Antonio Leon-Reyes Corné M J Pieterse Michel A Haring Ingo Heilmann Dorothea Bartels Teun Munnik

Plants respond to wounding by means of a multitude of reactions, with the purpose of stifling herbivore assault. Phospholipase D (PLD) has previously been implicated in the wounding response. Arabidopsis (Arabidopsis thaliana) AtPLDalpha1 has been proposed to be activated in intact cells, and the phosphatidic acid (PA) it produces to serve as a precursor for jasmonic acid (JA) synthesis and to ...

Journal: :Pharmacological reports : PR 2013
Marek Krzystanek Ewa Krzystanek Henryk I Trzeciak Andrzej Małecki Irena Krupka-Matuszczyk Małgorzata Janas-Kozik Janusz K Rybakowski

BACKGROUND Phospholipase D (PLD) plays a key role in a second messenger system producing phosphatidic acid, mediating, among others, serotonin 5-HT2 receptor activity. The aim of the study was to evaluate a possible effect of atypical antipsychotic drug, olanzapine (OLZ), and selective serotonin reuptake inhibitor (SSRI) antidepressant, paroxetine (PX), on oleate-activated PLD activity in plasm...

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