نتایج جستجو برای: phosphatidylserine
تعداد نتایج: 4913 فیلتر نتایج به سال:
OBJECTIVE Platelet activation is essential for primary hemostasis and acute thrombotic vascular occlusions. On activation, platelets release their prothrombotic granules and expose phosphatidylserine, thus fostering thrombin generation and thrombus formation. In other cell types, both degranulation and phosphatidylserine exposure are modified by sphingomyelinase-dependent formation of ceramide....
Acidic phospholipid binding plays an important role in determining the tissue distribution of basic drugs. This article describes the use of surface plasmon resonance to measure binding affinity (KD) of three basic drugs to phosphatidylserine, a major tissue acidic phospholipid. The data are incorporated into mechanistic tissue composition equations to allow prediction of the steady-state volum...
Dilute ( ~10% w/v) unsonicated phosphatidylserine dispersions in Hz0 contain spherical particles of a wide size distribution (0.1 to 15 q). The majority have diameters between 0.1 to 2 pm and lack the multilamellar arrangement of bilayers typical of unsonicated lecithin dispersions. Sonication uroduces small thermodynamically unstable vesicles surrounded by a single closed bilayer with an avera...
The transbilayer movement of phosphatidylserine from the inner to the outer leaflet of the membrane bilayer during platelet activation is associated with the release of procoagulant phosphatidylserine-rich small membrane vesicles called platelet-derived microvesicles. We tested the effect of lactadherin, which promotes the phagocytosis of phosphatidylserine-expressing lymphocytes and red blood ...
We are very excited to announce to you the release of our two newest products, Phosphatidylserine and DHA 710 Select. As you will see, it is not a coincidence that we are releasing these two products at the same time. Of course, as most of you know, these two nutrients have been important staples in the practice of clinical nutrition for several years now. However, most of the information on th...
Apoptosis, or programmed cell death, is a general mechanism for removal of unwanted cells from the immune system. It is characterized by chromatin condensation, a reduction in cell volume, and endonuclease cleavage of DNA into oligonucleosomal length fragments. Apoptosis is also accompanied by a loss of membrane phospholipid asymmetry, resulting in the exposure of phosphatidylserine at the surf...
Programmed cell death (apoptosis) functions as a mechanism to eliminate unwanted or irreparably damaged cells ultimately leading to their orderly phagocytosis in the absence of calamitous inflammatory responses. Recent studies have demonstrated that the generation of free radical intermediates and subsequent oxidative stress are implicated as part of the apoptotic execution process. Oxidative s...
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