Background: The use of NGS technology has rapidly increased during the last decade, and many new monogenic neurodevelopmental disorders have emerged. Pathogenic variants in neuronal CAMK2A gene been recently associated with “intellectual developmental disorder, autosomal dominant 53″ (OMIM#617798), a syndrome characterized by variable clinical manifestations including mild to severe intellectua...

As coral reefs experience dramatic declines in cover throughout the tropics, there is an urgent need to understand role that non-reef habitats, such as mangroves, play ecological niche of corals. Mangrove habitats present a challenge reef-dwelling corals because they can differ dramatically from adjacent reef with respect key environmental parameters, light. Because variation light within known...

Among the most interesting biological phenomena is the fact that a genotype can develop different phenotypes depending on the environment in which this development takes place. Historically, however, the focus was on homeostasis by canalization of the phenotype to a presumed optimum (Waddington, 1960), and phenotypic plasticity was interpreted as deviation ftom such an optimum and therefore con...

A potentially important mechanism controlling ion channel expression is homeostatic regulation, which can act to maintain a stable electrophysiological phenotype in cardiac myocytes as well as to provide plasticity in response to genetic, pathological, or pharmacological insults. The capabilities and limitations of the homeostatic regulatory mechanisms that contribute to the control of cardiac ...

Understanding how populations adapt to changing environments is a major goal in evolutionary biology and ecology, and particularly urgent for predicting resilience to climate change. Phenotypic plasticity, the ability to express multiple phenotypes from the same genome, is a widespread adaptation to shortterm environmental fluctuations, but whether it facilitates adaptation to environmental cha...

We conceptualize brain plasticity as an intrinsic property of the nervous system enabling rapid adaptation in response to changes in an organism's internal and external environment. In prenatal and early postnatal development, plasticity allows for the formation of organized nervous system circuitry and the establishment of functional networks. As the individual is exposed to various sensory st...

Phenotypic plasticity, the ability of cells to reversibly alter their phenotypes in response to signals, presents a significant clinical challenge to treating solid tumors. Tumor cells utilize phenotypic plasticity to evade therapies, metastasize, and colonize distant organs. As a result, phenotypic plasticity can accelerate tumor progression. A well-studied example of phenotypic plasticity is ...