In the analysis of finished pharmaceutical products, numerous innovative analytical techniques are often used, i.e., Raman spectroscopy, scanning electron microscopy, computer microtomography, directional hemispherical reflectance, and hyperspectral analyses. These allow for identification changes in solid phases. Many advantages over other can be attributed to these techniques, e.g., they rapi...

INTRODUCTION Contamination of pharmaceutical preparations by micro-organisms continues to be a matter of concern to the pharmacists. From the beginning it has been an official requirement that parenteral preparations shall be sterile. More recently a number of serious infections in the eye in Britain and elsewhere have resulted in the further requirement that all preparations used in the eye sh...

The term “immediate release” pharmaceutical formulation includes any in which the rate of release drug from or absorption drug, is neither appreciably, nor intentionally, retarded by galenic manipulations. These tablets disintegrate rapidly and get dissolved to medicaments. It may be provided for way an appropriate pharmaceutically acceptable diluent carrier, carrier does not prolong, appreciab...

In the past few years, there are number of researchers carrying out their research on the excipients derived from polysaccharides and some of these researches show that natural excipients are comparable and can serve as an alternative to the synthetic excipients. Hence, the objectives of this research are to characterize the naturally sourced chickpea starch powder and to study the pharmaceutic...

This study deals with characterization and quantification of form I and form II of clopidogrel bisulphate (CLP), a selective and irreversible inhibitor of ADP-induced platelet aggregation. Thermal (DSC, TGA, HSM), crystallographic (XRD) and spectroscopic (FTIR) methods were used for characterization. After characterization of active pharmaceutical ingredient (API), these techniques were further...

By analyzing spatio-temporal characteristics of short optical pulses diffusively transmitted through compacted granular materials, we reveal that powder compaction can give rise to strongly anisotropic light diffusion. Our disclosure represents a revision of the understanding of optics of powder compacts. Routes to material characterization and investigation of compression-induced structural an...

A new quantitative method using silica gel high-performance thinlayer chromatography (HPTLC) plates with fluorescent indicator, channels, and a concentration zone; instrumental bandwise application of standards and samples; development with dichloromethane–acetone, 4:1, as mobile phase; and ultraviolet absorption densitometry of fluorescence quenched zones is reported for determination of salic...

A simple and rapid HPLC method for the determination of simvastatin using a C18-Hypersil column and acetonitril–phosphate buffer–methanol (5 : 3 : 1, v/v/v) as a mobile phase with detection at 230 nm was proposed. Commercial pharmaceutical tablets were analyzed with a linear range for simvastatin up to 1.884 mg % and a regression coefficient of 0.9995. The method is found to be precise, accurat...

A simple, rapid and validated HPLC method was developed for determination of Piracetam in film coated tablets. A Lichrosorb® (RP-18 column with a mobile phase consisting of acetonitrile – phosphate buffer (5:95v/v)) was used. Quantitative evaluation was performed at 205 nm. The HPLC method is selective, precise and accurate and can be used for routine analysis of preparations in pharmaceutical ...