نتایج جستجو برای: pharmaceutical protein
تعداد نتایج: 1293411 فیلتر نتایج به سال:
fluorescence chemical sensors for the highly sensitive and selective determination of pb2+ , hg2+, co2+ and fe3+ ions in aqueous solutions are described. the ion sensing system was prepared by incorporating lipophilic ligand (l) as a neutral ion-selective fluoroionophore in the plasticized pvc membrane containing sodium tetraphenylborate or potasium tetrakis (p-chlorophenyl) borate as a liphoph...
Yeast has great utility as a surrogate system to study aspects of mammalian biology. This utility extends to the drug discovery process, where yeast has been used to reveal the mechanism of action of compounds, to discover and characterize components of signaling pathways and to dissect protein function. These applications of yeast are illustrated by examples of research published by major phar...
1Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo; 2Faculty of Health Sciences, Hokkaido University, Sapporo; 3Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo; 4Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa; and 5Laboratory of Frontier Science, Tokyo Metro...
Introduction Sepsis is a syndrome of systemic inflammation arising from infection that constitutes a top-ten cause of adult mortality. The recent withdrawal of a specific sepsis therapeutic has diminished pharmaceutical enthusiasm for developing novel drugs in this domain. Angiopoietin-2 (Angpt-2) is an endothelial-derived protein that potentiates vascular inflammation and permeability and may ...
Structural MS is a rapidly growing field with many applications in basic research and pharmaceutical drug development. In this feature article the overall technology is described and several examples of how hydroxyl radical based footprinting MS can be used to map interfaces, evaluate protein structure, and identify ligand dependent conformational changes in proteins are described.
A microfluidic platform was used to address the problems of obtaining diffraction-quality crystals and crystal handling during transfer to the X-ray diffractometer. Crystallization conditions of a protein of pharmaceutical interest were optimized and X-ray data were collected both in situ and ex situ.
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