Dr. Nash welcomed the attendees and program participants. He noted that the speakers were prepared to demonstrate that genomics research represents the solution for the diminished drug pipeline in the pharmaceutical industry. Breakthroughs in new drug development will be occurring at the intersection of human genetics, functional genomics, and proteomics. Scheduled were sessions covering the pr...

background and objectives: pharmaceutical expenditures are responsible for a major part of health systems’ cost. according to the who’s statistics, iran is the first among the 20 countries in the world in terms of drug consumption. the first step in controlling consumption of a particular good is to identify factor inducing the relevant demands. hence, this study aimed to identify the pattern a...

Drug combinations are highly efficient in systemic treatment of complex multigene diseases such as cancer, diabetes, arthritis and hypertension. Most currently used combinations were found in empirical ways, which limits the speed of discovery for new and more effective combinations. Therefore, there is a substantial need for efficient and fast computational methods. Here, we present a principl...

INTRODUCTION There is strong pharmaceutical development of agents targeting the IL-17-TH17 pathway for the treatment of psoriasis (Ps) and psoriatic arthritis (PsA). Lung cancer accounts for 28% of all cancer-related deaths worldwide, and roughly 80% of patients with newly-diagnosed non-small cell lung cancer (NSCLC) present with metastatic disease, with a poor prognosis of around 12 months. Th...

the purpose of this research was to study the neutralization efficacy of a universal neutralizer proposed by the ctpa on a range of antimicrobial agents and its potential toxicity for microorganisms that are used for antimicrobial preservation testing. several types of antimicrobial agents including a mixture of methylisothiazolinone and its 5-chloro derivative, dimethylol dimethyl hydantoin, q...

BACKGROUND Spending on specialty pharmaceuticals is rising faster than that for traditional drugs. In 2006, specialty drugs were the largest category driving drug costs and utilization trends. Even with effective management, expenditures on these agents are projected to increase exponentially in the coming years. OBJECTIVE To review benefit design strategies used by payers to control costs an...

Benzimidazoles and their derivatives play an extraordinarily significant role as therapeutic agents, e.g., antiulcer, analgesic, anthelmintic drugs. The organic synthesis of benzimidazoles to obtain active pharmacological compounds represents important research area in chemistry. use non-environmental application high energy synthetic methods, the production waste, conventional toxic processes ...

Aminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNA. They play a pivotal role in protein synthesis and are essential for cell growth and survival. The aaRSs are one of the leading targets for development of antibiotic agents. In this review, we mainly focused on aaRS inhibitor discovery and development using in silico methods including ...

Flavonoids are ubiquitous plant secondary metabolites and have been recognized to be potent pharmaceutical agents by several research groups. Methylation of the flavonoids via theirs frees hydroxyl groups or carbon atom dramatically increases their metabolic stability and enhances the membrane transport, leading to facilitated absorption and greatly increased oral bioavailability. Glycosylation...

Fast track appraisal (FTA) was adopted by NICE in 2017. This faster and more simplified process is mainly used for novel pharmaceutical agents that are considered bioequivalent to an already recommended drug with added advantages or reduced costs. In June 2022 FTA recommend diroximel fumarate (Vumerity) the management of relapsing remitting multiple sclerosis (RRMS). short article explores pote...