نتایج جستجو برای: ph sensitive liposome

تعداد نتایج: 445693  

Journal: :ACS nano 2011
Sang-Min Lee One-Sun Lee Thomas V O'Halloran George C Schatz Sonbinh T Nguyen

Nanoscale drug delivery platforms can provide an attractive therapeutic strategy for cancer treatments, as they can substantially reduce the adverse side effects associated with toxic small-molecule anticancer agents. For enhanced therapeutic efficacy to be achieved with such platforms, a tumor-specific drug-release trigger is a critical requirement. This article reports the use of a pH-sensiti...

2012
Junkun He David L Evers Timothy J O’Leary Jeffrey T Mason

BACKGROUND The accurate quantification of antigens at low concentrations over a wide dynamic range is needed for identifying biomarkers associated with disease and detecting protein interactions in high-throughput microarrays used in proteomics. Here we report the development of an ultrasensitive quantitative assay format called immunoliposome polymerase chain reaction (ILPCR) that fulfills the...

Journal: :Journal of molecular biology 2011
C Preston Moon Sarah Kwon Karen G Fleming

The free energy of unfolding of a membrane protein from lipids into water (ΔG(o)(w,l)) describes its equilibrium thermodynamic stability. Knowing this parameter gives insight into a membrane protein's sequence-structure-energy relationships. However, there are few measures of membrane protein stability because of the technical difficulties associated with unfolded and partially folded states. H...

2013
Dominik Lipka Jerzy Gubernator Nina Filipczak Sabine Barnert Regine Süss Mateusz Legut Arkadiusz Kozubek

The encapsulation of anticancer drugs in a liposome structure protects the drug during circulation and increases drug accumulation in the cancer tissue and antitumor activity while decreasing drug toxicity. This paper presents a new method of active drug loading based on a vitamin C pH/ion gradient. Formulations were characterized in terms of the following parameters: optimal external pH, time ...

Journal: :Life sciences 1977
J H Fendler A Romero

Liposomes are artificially prepared vesicles made of lipid bilayer. Liposomes can be filled with drugs, and used to deliver drugs for cancer and other diseases. Amongst the various carrier, few drug carrier reached the stages of clinical trails where phospholipid vesicles (liposome) show strong potential for effective drug delivery to the site of action. Liposomes can be composed of naturally-d...

Journal: :Chemical communications 2011
Jiseok Lee Eun Jeong Jeong Jinsang Kim

We report a convenient melamine detection system based on polydiacetylene (PDA) liposomes having rapid, selective, and sensitive detection, and dual signal capabilities. The detection limit of the sensory PDA liposome is 1 and 0.5 ppm in the colorimetric and the fluorescence detection schemes, respectively, satisfying the world regulation level.

Journal: :Chemical communications 2015
Sungbaek Seo Min Sang Kwon Andrew W Phillips Deokwon Seo Jinsang Kim

We developed a new self-signaling sensory system built on phospholipid liposomes having H-aggregated R6G dyes on their surface. Selective molecular recognition of a target by the phospholipid displaces R6G from the liposome surface to turn on fluorescence signal. Selective and sensitive detection of neomycin down to 2.3 nM is demonstrated.

Journal: :Biochimica et biophysica acta 2004
Nancy Dos Santos Kelly A Cox Cheryl A McKenzie Floris van Baarda Ryan C Gallagher Goran Karlsson Katarina Edwards Lawrence D Mayer Christine Allen Marcel B Bally

Application of cholesterol-free liposomes as carriers for anticancer drugs is hampered, in part, because of standard pH gradient based loading methods that rely on incubation temperatures above the phase transition temperature (Tc) of the bulk phospholipid to promote drug loading. In the absence of cholesterol, liposome permeability is enhanced at these temperatures which, in turn, can result i...

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