نتایج جستجو برای: pgj2

تعداد نتایج: 308  

Journal: :Molecular pharmacology 2007
Yuji Tanaka Jonathan M Maher Chuan Chen Curtis D Klaassen

Hepatic ischemia-reperfusion (IR) results in Kupffer cell activation and subsequent tumor necrosis factor (TNF) alpha release, leading to localized hepatic injury and remote organ dysfunction. Heme oxygenase (HO)-1 is an enzyme that is induced by various stimuli, including proinflammatory cytokines, and exerts antioxidative and anti-inflammatory functions. Up-regulation of HO-1 is known to prot...

Journal: :The Journal of biological chemistry 2017
Jianhong Lu Shuyuan Guo Xinli Xue Qun Chen Jing Ge Yujuan Zhuo Huiqin Zhong Buxing Chen Mingming Zhao Wei Han Takashi Suzuki Mingjiang Zhu Lin Xia Claus Schneider Timothy S Blackwell Ned A Porter Lemin Zheng Sotirios Tsimikas Huiyong Yin

Oxidative stress and inflammation are two major contributing factors to atherosclerosis, a leading cause of cardiovascular disease. Oxidation of phospholipids on the surface of low density lipoprotein (LDL) particles generated under oxidative stress has been associated with the progression of atherosclerosis, but the underlying molecular mechanisms remain poorly defined. We identified a novel s...

Journal: :Schizophrenia bulletin 2014
Borja García-Bueno Miquel Bioque Karina S Mac-Dowell M Fe Barcones Monica Martínez-Cengotitabengoa Laura Pina-Camacho Roberto Rodríguez-Jiménez Pilar A Sáiz Carmen Castro Amalia Lafuente Javier Santabárbara Ana González-Pinto Mara Parellada Gabriel Rubio M Paz García-Portilla Juan A Micó Miguel Bernardo Juan C Leza

BACKGROUND Schizophrenia is a chronic syndrome of unknown etiology, predominantly defined by signs of psychosis. The onset of the disorder occurs typically in late adolescence or early adulthood. Efforts to study pathophysiological mechanisms in early stages of the disease are crucial in order to prompt intervention. METHODS Case-control study of first-episode psychotic (FEP) patients and mat...

2006
SOL UMEREZ MARÍA ADELA JASNIS ALBERTO CASABÉ ANA MARÍA EIJÁN

Bacillus Calmette-Guérin (BCG) is considered to be one of the most effective treatments for superficial and in situ bladder cancer. The exact mechanism of the antitumor activity of BCG is not completely understood. Peroxisome proliferatoractivated receptor gamma (PPARÁ) is a member of the nuclear receptor superfamily of ligand-activated transcription factors that is involved in cell growth and ...

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