introduction: the key characteristics of positron emission tomography (pet) are its quantitative capability and its sensitivity, which allow the in vivo imaging of biochemical interactions with small amounts of tracer concentrations. therefore, accurate quantification is important. however, it can be sensitive to several physical factors. the aim of this investigation is the assessment of the e...

Abnormal accumulation of tau aggregates in the brain is one of the hallmarks of Alzheimer disease neuropathology. We visualized tau deposition in vivo with the previously developed 2-arylquinoline derivative (18)F-THK5117 using small-animal PET in conjunction with autoradiography and immunohistochemistry gold standard assessment in 2 transgenic mouse models expressing hyperphosphorylated tau. S...

Accurate assessment of kidney function plays an essential role for optimal clinical decision making in a variety of diseases. The major intrinsic advantages of PET are superior spatial and temporal resolutions for quantitative tomographic renal imaging. 2-deoxy-2-18F-fluorodeoxysorbitol (18F-FDS) is an analog of sorbitol that is reported to be freely filtered at the renal glomerulus without rea...

BACKGROUND Compartmental analysis is a standard method to quantify metabolic processes using fluorodeoxyglucose-positron emission tomography (FDG-PET). For liver studies, this analysis is complex due to the hepatocyte capability to dephosphorylate and release glucose and FDG into the blood. Moreover, a tracer is supplied to the liver by both the hepatic artery and the portal vein, which is not ...

This study aimed to stereotactically compare the PET imaging performance of (18)F-Alfatide ((18)F-ALF-NOTA-PRGD2, denoted as (18)F-Alfatide) and (18)F-fluorodeoxyglucose (FDG) and immunohistochemistry (IHC) staining in Lewis lung carcinoma (LLC) tumor-bearing C57BL/6 mouse model. (18)F-FDG standard uptake values (SUVs) were higher than (18)F-Alfatide SUVs in tumors, most of the normal tissues a...

INTRODUCTION Myocardial perfusion scintigraphy (MPS) is an established non-invasive technique for the diagnosis and management of patients with suspected or known coronary artery disease. Because of the wealth of prognostic data, MPS single photon emission computed tomography (SPECT) is the most commonly used functional test to detect inducible ischaemia. However, the increasing availability of...

This study aims at developing a simulation system that predicts the optimal study design for attaining tracer steady-state conditions in brain and blood rapidly. Tracer kinetics was determined from bolus studies and used to construct the system. Subsequently, the system was used to design inputs for bolus infusion (BI) or programmed infusion (PI) experiments. Steady-state quantitative measureme...

The aim of the present study was to determine the tumour specificity of the newly developed nucleoside metabolic positron emission tomography (PET) tracer, 3'-deoxy-3'-18F-fluorothymidine (18F-FLT). Using 18F-FLT PET imaging, DNA synthesis and cell proliferation were detected in Staphylococcus aureus (S. aureus) abscess and calcium sulphate models in Wister rabbits. A total of eight rabbits wer...

Dynamic Positron Emission Tomography (PET) has opened the possibility of quantifying physiological processes within the human body. On performing dynamic PET studies, the tracer concentration in blood plasma has to be measured, and acts as the input function for tracer kinetic modelling. In this paper, we propose an approach to estimate physiological parameters for dynamic PET studies without t...

Abstract Various positron emission tomography (PET) tracers have been developed and extensively studied in the field of neuro-oncology imaging. In management brain tumors, accurate delineation tumor extent, assessment treatment response, detection early recurrence are most important factors. At present, conventional anatomical imaging paired with amino acid tracer PET is recommended modality fo...