Intravenous injection of alloxan into rabbits, rats, dogs, monkeys, etc., produces a brief hyperglycemia, then a transient hypoglycemia, which in the case of rabbits is severe enough to cause convulsions and death, unless counteracted by repeated injections of glucose, and finally a permanent diabetic hyperglycemia. The cause of the transient hypoglycemia has had various explanations. Goldner a...

Introduction: Tumor-induced hypoglycemia is a rare entity and it is mainly due to pancreatic insulinomas. Non-islet cell tumor hypoglycemia is really exceptional and ectopic insulin secretion has been previously suggested. Case Presentation: A 79 year-old type 2 diabetic man, after over 30 years of poorly controlled diabetes, observed an unexplained improving of glycemic control with recurrent ...

background: hypoglycemia is one of the most common neonatal disorders, associated with severe complications. there has been a great deal of controversy regarding the definition and screening of hypoglycemia. therefore, in this study, we aimed to determine a cut-off value for blood glucose level in glucometer readings. methods: this cross-sectional study was conducted on 238 newborns at risk of ...

The relationship between the human brain response to acute stress and subjective, behavioural and physiological responses is poorly understood. We have examined the human cerebral response to the intense interoceptive stressor of hypoglycemia, controlling plasma glucose at either normal fasting concentrations (5 mmol/l, n=7) or at hypoglycemia (2.7 mmol/l, n=10) for 1 h in healthy volunteers. H...

BACKGROUND Severe postprandial hypoglycemia after bariatric surgery is a rare but invalidating complication. Our aim was to describe the different tests performed for its diagnosis and their outcomes as well as the response to the prescribed pharmacological and surgical treatments. METHODS Multicenter, retrospective systematic review of cases with recurrent severe postprandial hypoglycemia. ...

I atrogenic hypoglycemia causes recurrent physical morbidity, and some mortality, as well as recurrent or persistent psychological morbidity in patients with IDDM (1). The frequency of iatrogenic hypoglycemia is substantially higher during effective intensive therapy of IDDM. Even in the highly structured Diabetes Control and Complications Trial the frequency of severe hypoglycemia was increase...

Thioredoxin-interacting protein (Txnip) is a ubiquitous protein that binds with high affinity to thioredoxin and inhibits its ability to reduce sulfhydryl groups via NADPH oxidation. HcB-19 mice contain a nonsense mutation in Txnip that eliminates its expression. Unlike normal animals, HcB-19 mice have approximately 3-fold increase in insulin levels when fasted. The C-peptide/insulin ratio is n...

Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is a disorder characterized by unregulated insulin release, leading to profound hypoglycemia with a major risk of brain damage if not recognized early. The occurrence of PHHI is low in the Western world (~1/50,000 live births), but it can be as high as 1/2,500 live births in communities with high consanguinity. PHHI may be differentiate...

From the Division of Endocrinology, Children’s Hospital of Philadelphia, Philadelphia, PA; Division of Neonatology, University of Colorado School of Medicine, Aurora, CO; Department of Endocrinology, Cook Children’s Medical Center, Fort Worth, TX; Newborn Intensive Care Unit, Waikato Hospital, Hamilton, New Zealand; Texas Children’s Hospital, Houston, TX; Department of Endocrinology, Great Ormo...