The role of active oxygen species and lipid peroxidation in the toxic effects of diquat, paraquat and other bipyridyl herbicides remains controversial. In vitro studies have shown that these compounds are potent generators of active oxygen species by redox cycling and that they stimulate lipid peroxidation. In vivo studies have failed, however, to show clear evidence of lipid peroxidation resul...

Although lipid peroxidation associated with oxidative stress can result in cellular death, sub-lethal lipid peroxidation can gradually resolve with return to the pre-exposure state. We have shown that resolution of lipid peroxidation is greatly delayed in lungs or cells that are null for peroxiredoxin 6 (Prdx6) and that both the phospholipase A2 and the GSH peroxidase activities of Prdx6 are re...

Exposure of red blood cells to oxygen radicals can induce hemoglobin damage and stimulate protein degradation, lipid peroxidation, and hemolysis. To determine if these events are linked, rabbit erythrocytes were incubated at 37 degrees C with various oxygen radical-generating systems and antioxidants. Protein degradation, measured by the production of free alanine, increased more than 11-fold i...

It is believed that free radical variations are the main cause of ageing, development of different diseases or even death. Free radicals affect biological process in a way that cells can loss their function and decrease their resistance to stress which can be related to ageing. Here the alterations of lipid peroxidation in different age and ethnic groups are review. There are many theories to e...

An increased concentration of end products of lipid peroxidation is the evidence most frequently quoted for the involvement of free radicals in human disease. However, it is likely that increased oxidative damage occurs in most, if not all, human diseases and plays a significant pathological role in only some of them. For example, peroxidation appears to be important in atherosclerosis and in w...

The methanolic extract of Sida retusa Linn.(Malvaceae),Urena lobata Linn.(Malvaceae)and Triumfetta rhomboidea Jacq.(Teliaceae) roots were found to inhibit lipid peroxidation, scavenge hydroxyl and superoxide radicals in vitro. The quantity of S.retusa root extract required for 50% inhibition of lipid peroxidation, scavenging hydroxyl radical and superoxide radical was 1130.24 ug/ml respectively...

The stimulation of microsomal lipid peroxidation by FeSO4 and cysteine has been investigated. Although both FeSO4 and cysteine alone promoted an increase in malonaldehyde production, when these agents were added together to microsomes the resultant level of malonaldehyde was greater than the sum of the amounts formed by these pro-oxidants when acting individually. A further indication of an int...

Herbicide, Diphenyl Ether, Peroxidation, Antioxidants Measurements of ethane and ethylene as indices o f in vivo lipid peroxidation and o f chemicallyinduced stress, respectively, were done on mustard seedlings (Sinapis alba), treated with oxyfluorfen[2-chloro-l-(3-ethoxy-4-nitrophenoxy)-4-(trifluoromethyl)benzene]. When seedlings were exposed to low light intensity o f 14 W /m 2, only stress-e...

The aim of this study was to estimate the effect of aquatic cadmium and lead pollution on superoxide dismutase (SOD) activity and lipid peroxidation in fish. The study used the fish species Cyprinus carpio L., Oncorhynchus mykiss Walbaum, and Acipenser baeri Brandt. SOD activity was measured by the adrenaline method. Lipid peroxidation was measured by determining malondialdehyde (MDA) concentra...

The protective effect of Calotropis gigantea flower extract in acute alcohol induced hepatotoxicity in rats was evaluated. A significant increase in the levels of enzyme markers of tissues damage (ALT, AST and ALP), lipid peroxidation (TBARS) and decreased serum vitamin C levels were observed in alcohol intoxicated rats as compared to control animals. Pretreatment with 250 and 500 mg/kg body we...