Peritoneal dissemination is a major cause of recurrence in patients with malignant tumors in the peritoneal cavity. Effective anticancer agents and treatment protocols are necessary to improve outcomes in these patients. However, previous studies using mouse models of peritoneal dissemination have not detected any drug effect against peritoneal micrometastasis. Here we used the luciferase assay...

anorexia developed, and the patient, too fatigued to prepare her meals, would often go to bed immediately upon returning from her work. Despite these symptoms she continued at her occupation until two weeks and a half before admission, when she was seized with severe pain in the right lower quadrant of the abdomen, which gradually spread to the upper right quadrant. It remained more or less con...

Ideally, an artificial kidney should simulate the normal kidney in providing continuous metabolic control, removal of toxins, and unrestricted patient freedom. Of the dialysis procedures available, continuous ambulatory peritoneal dialysis (CAPD) comes the closest to this ideal but provides inadequate dialysis and fails to remove protein-bound toxins. A continuous, wearable, peritoneal-based ar...

Immune complex (IC) deposition causes significant tissue injury associated with various autoimmune diseases such as vasculitis. In the cascade of inflammation, cell-to-cell and cell-to-matrix adhesion via adhesion molecules are essential. To assess the role of αE and β7 integrin in IC-mediated tissue injury, peritoneal and cutaneous reverse-passive Arthus reaction was examined in mice lacking α...

bearing L1210 or L1210/MTX leukemia to study DNA synthesis in vivo. In mice bearing a large population of leukemia cells, most of the retained radioactivity could be recovered from the DNA of these cells. Total body retention and the anatomical distribution of radioactivity in leukemic mice were highly dependent upon the route of iododeoxyuridine administration. Intraperitoneal injections into ...

The success of peritoneal dialysis depends on the presence of functional long-term catheter access to the peritoneal cavity. Mechanical problems of peritoneal dialysis catheter are the second most common cause of depriving patients from peritoneal dialysis, next to infectious problems.1 Intraluminal fibrin clot is one type of mechanical problems that mostly treated conservatively by nonsurgical...

that pleural exudate from patients with thoracic tumors may contain free tumor cells, some of which show mitotic figures. The study of the diagnostic significance of these cells has long been a part of exfoliative cytology (1, 10). How ever, our extensive search in the literature on cancer did not reveal any mention of experiments concerning the growth potentialities of free tumor cells floatin...

Leiomyomatosis peritonealis disseminata is a very rare condition characterized by the development of multiple smooth muscle-like nodules in the peritoneal cavity. It is associated with increased serum levels of gonadal steroids. The present report describes a 29-year-old patient underwent transabdominal hysterectomy and Bilateral Salpingo oophorectomy six years ago because of leiomyomatosis per...

The monocot lectin from the tubers of Arisaema erubescens (Wall.) Schott has been purified by consecutive hydrophobic chromatography and ion exchange chromatography methods. The molecular weight of this A. erubescens lectin (AEL) was determined to be about 12 kDa by high performance liquid chromatography (HPLC) and sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) methods. A...