Platelet functions, including adhesion, activation, and aggregation have an influence on thrombosis and the progression of atherosclerosis. In the present study, a new microfluidic-based method is proposed to estimate platelet adhesion and blood viscosity simultaneously. Blood sample flows into an H-shaped microfluidic device with a peristaltic pump. Since platelet aggregation may be initiated ...

The effects of the beta-1 adrenergic agonist prenalterol and the beta-2 adrenergic agonist terbutaline on oesophageal peristalsis were studied in nine healthy volunteers with pressures recorded in the proximal, middle, and distal oesophagus. Two doses of the agonists were given after pretreatment with placebo, propranolol, or metoprolol in a double blind randomised fashion. Terbutaline 0.25 +/-...

Cryogel beads, fabricated by the microchannel liquid-flow focusing and cryo-polymerization method, have micron-scale supermacropores allowing the passage of crude feedstocks, and could be of interest as chromatographic adsorbents in bioseparation applications. In this work, we provide a rapid freezing and continuous formation method for cryogel beads by cryo-polymerization using dry ice particl...

This study attempts to analyze the effect of diverse parameters peristaltic flow second grade dusty fluid through a curved configuration. Stream function conversions are used model separate system equations for dust particles and fluid. The Perturbation technique is get analytical solutions results verified graphs. It noticeable that trapped bolus, compresses both with an increase in `the param...

Sudha Ramasamy, Karthikesh.R, Manikandan.P, Padma Thiagarajan School of Electrical Engineering, VIT University, Vellore, India. School of Biosciences and Technology, VIT University, Vellore, India E-Mail: [email protected] Abstract The aim of this work is to transfer liquid contents from one micro cell to another using two stepper motors and a peristaltic pump. There are two objectives here. One...

The relationship between slow waves and peristaltic reflexes has not been well analyzed. In this study, we have recorded the electrical activity of slow waves together with that generated by spontaneous peristaltic contractions at 240 extracellular sites simultaneously. Recordings were made from five isolated tubular and six sheet segments of feline duodenum superfused in vitro. In all preparat...

The present study investigates the peristaltic transport of non-Newtonian fluid, modeled as power law and Bingham fluid, in a diverging tube with different wall wave forms: sinusoidal, multi-sinusoidal, triangular, trapezoidal and square waves. Fourier series is employed to get the expressions for temporal and spatial dependent wall shapes. Solutions for time average pressure rise — flow rate r...

Microfluidic systems with integrated analysis and control of environmental parameters can enable precise control of metabolic activity and protein expression. Here, we couple microfluidic controls in a polycarbonate-PDMS microbioreactor (Fig. 1) with closed-loop control of temperature, pH, dissolved oxygen, and cell density [1,2] to the biochemical control of synthetic gene circuits [3,4]. In s...

The development of a competitive solid-phase immunoassay for digoxin making use of the acridinium chemiluminescence system is described. Two different instrumental approaches are compared. One is based on a continuous flow system using a peristaltic flow injection analysis pump; the other uses a new sequential injection technique. In both systems a flow cell, consisting of transparent PTFE tubi...

The intestinal peristaltic reflex induced by mucosal stimulation is mediated by mucosal release of serotonin (5-HT), which acts on 5-HT(4) receptors located on CGRP-containing afferent nerve terminals. Exposure of the colonic mucosa to the 5-HT(4) receptor agonist tegaserod in the range of 1 nM to 10 muM elicits a peristaltic reflex and stimulates colonic propulsion. The present study was desig...