AMULET1, developed in the OMI-MAP project, showed that complex asynchronous design is feasible. AMULET2e, developed in the OMI-DE project, is the next step in establishing self-timed processing as a commercially viable technology. It incorporates a new core, AMULET2, which is significantly faster than AMULET1, together with on-chip RAM which can be configured as a fixed block of RAM or as a cac...

Abstract Symptomatic presentation of patients with intra-cranial malignancy is frequently non-specific and differentiating such from those benign conditions challenging. Accordingly, GBM presents as a medical emergency more than any other common cancer, implying that effective strategies for rapid simple diagnostic stratification are urgently required. Here we describe the detection glial malig...

patients and methods in this cross-sectional study, peripheral mononuclear cells (pbmcs) were isolated from peripheral blood of 29 patients with newly diagnosed pulmonary tb and 19 patients with positive tuberculin skin test. the pbmcs were activated with ppd for 72 hours. activated cells were harvested, rna was extracted and cdna was synthesized. a real-time taqman method was designed and opti...

IntroductionThis study aimed to analyse cervical lymphocytic populations in HIV+ and HIV− patients correlate different lesions with HIV viral load presence of high-risk HPV types.Material methodsA total 132 histological specimens from 40 72 were evaluated for CD4+ CD8+ T cell distribution, types, peripheral blood CD4+/CD8+ ratio.ResultsHigh-grade squamous intraepithelial (HSIL) carcinoma (SCC) ...

Background: Dendritic cells (DCs) are the most potent stimulators of primary T cell responses and play a key role in immune reactions after stem cell transplantation. Very little is known about the cord blood (CB) dendritic cells and their potential involvement in the low incidence and lower severity of acute graft-versus-host disease after CB transplantation.   Objectives: The aim of this stud...

BACKGROUND Peripheral blood interferon-gamma release assays (IGRAs) have sub-optimal sensitivity and specificity for diagnosis of active pulmonary tuberculosis (TB). However, assessment of local immune responses has been reported to improve the accuracy of TB diagnosis. METHODS We enrolled HIV-infected adults with cough ≥2 weeks' duration admitted to Mulago Hospital in Kampala, Uganda and ref...

Arginase I (Arg I) and inducible nitric oxide synthase (iNOS) are important in regulating immune functions through their metabolites. Previous studies have revealed that the expression of Arg I is increased and the expression of iNOS is reduced in the serum and peripheral blood mononuclear cells of human immunodeficiency virus (HIV)‑infected patients. As one of the most important immune organs ...

Mesenchymal stem cells (MSCs) provide a novel option in cellular therapy and tissue engineering. Recent studies indicated that it is possible to obtain MSCs from peripheral blood by attachment ability to plastic surface. To evaluate adherent cells derived from peripheral blood, their expression profile and surface markers were investigated. The results of RT-PCR indicated that these cells expre...

Background: Atherosclerosis, a chronic inflammatory disease of the vessel wall is characterized by local and systemic immune responses to a variety of antigens. Oxidized low-density lipoprotein (oxLDL) is considered as an important determining factor in the pathogenesis of atherosclerosis. Objective: The purpose of this study was to investigate the degree of peripheral blood mononuclear cells (...

Background: Patients with rheumatoid arthritis (RA) suffer from wide ranges of autoimmune reactions in joints. The mechanism of which is generally unknown and maybe associated with Treg deregulation. Objective: To compare the frequency of nTregs in peripheral blood of patients with active rheumatoid disease with healthy individuals. Methods: Twenty five newly diagnosed patients with active RA d...