Methods: This randomized clinical study included 150 perimenopausal women with endometrial hyperplasia (EH) without atypia who were randomly assigned into three groups; 50 patients received 15 mg Medroxyprogesterone acetate (MPA), 50 patients received 15 mg Norethisterone acetate (NETA) and 50 patients in whom levonorgestrel-releasing intrauterine system (LNG-IUS) was inserted. Endometrial samp...

Invasive mole, classified under the gestational trophoblastic diseases, comprises of hydropic chorionic villi invading underlying myometrium, blood vessels or extra-uterine sites. They are usually diagnosed clinically and treated with chemotherapy. Thus, surgery is rarely performed owing to good response chemotherapy preservation fertility, since most women in reproductive age. these specimens ...

This study was conducted to examine the estradiol level and plasma lipid profile in perimenopausal women. The estradiol and HDL levels were higher and LDL levels lower in premenopausal women than in postmenopausal women of the same age group. Higher HDL and lower LDL levels in premenopausal women are likely to protect them against atherosclerosis, and the difference may be casually related to e...

Depression affects one in every five adults in North America. Women are more affected than men, possibly because of genetics, coping strategies, and hormone variations. The concept of a menopause-associated depression, however, remains a complex and controversial topic. Although hormone therapy is not recommended as first-line therapy for depression in midlife women, estrogen-based hormone ther...

A 54-years-old perimenopausal female was referred to the pneumology outpatient clinic for further evaluation of incidental lung nodules. Chest X-ray showed multiple bilateral shadows in the pulmonary parenchyma (Figure 1). Asked about any clinical symptom, she just referred a light dyspnea in high exercise situations. She had no personal history of pulmonary disease, being all the respiratory t...

Mixed epithelial and stromal tumour of the kidney (MESTK), is a rare kidney tumour. About 100 cases so far have been reported in the literature. Although MESTK mostly presents in perimenopausal age group some rare cases in young females have been reported. We report a rare presentation of a 25 cm size giant MESTK arising from the left kidney in a young female in the absence of any clinically de...

Abnormal uterine bleeding (AUB) is responsible for 33% of all outpatient gynecologic visits, with the majority of cases just after menarche or in the perimenopausal period.1 Most cases are related to pregnancy, anatomic uterine pathology (fibroids, polyps, adenomyosis), anovulation, maladies of hemostasis, or neoplasia. Since evaluation of the endometrium is a key component in the diagnostic tr...

AMA Lakhno I, Korovai S, Struk T, Pak S. The pathogenic pathways of cardiovascular disease in perimenopausal women. Menopause Review/Przegląd Menopauzalny. 2023;22(2):59-63. doi:10.5114/pm.2023.127902. APA Lakhno, I., Korovai, S., Struk, T., & Pak, (2023). Menopauzalny, 22(2), 59-63. https://doi.org/10.5114/pm.2023.127902 Chicago Igor, Sergei Tetiana and Svitlana Pak. 2023. "The women". Menopau...

Background: The menopausal transition called perimenopause, happens after the reproductive years, and isspecified with irregular menstrual cycles, perimenopause symptoms and hormonal changes. Women going throughperi menopausal period are vulnerable to bone loss.Osteoporosis is one of the most common debilitating metabolic bone diseases ,especially in the women almostaround 50 years .This study ...