The article entitled Perihepatic lymphadenopathy in children with chronic viral hepatitis(1) is an original paper of high clinical relevance – viral hepatitis B and C are the main causes of chronic hepatitis and liver cirrhosis in children. Based on ultrasound fi ndings, the authors assessed the presence of the perihepatic lymph nodes and their morphology in 49 children with chronic viral hepat...

Hepatobiliary scintigraphy is a sensitive method for intra & extera hepatic bile leak diagnosis. Bile lead may be seen after hepatobiliary surgery, trauma, inflammatory disease or malignant neoplasms. Although sonography and CT scanning are useful for diagnosis of peritoneal or perihepatic fluid, they cannot prove bile ascites. Hepatobiliary scintigraphy with Tc-99m-IDA agents is a physio...

We have developed a sandwich-enzyme immunoassay (EIA) for the quantification of lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) in human postheparin plasma (PHP) using monoclonal antibodies (MAbs) directed against the corresponding enzymes purified from human PHP. The sandwich-EIA for LPL was performed by using the combination of two distinct types of anti-LPL MAbs that recogniz...

I nferior vena cava (IVC) thrombosis associated with filters is not uncommon in clinical practice. However, suprarenal extension of the thrombosis to the hepatic segment of the IVC is very rare, particularly in absence of renal or hepatic tumors (1). Benign intrinsic IVC stenosis is a rare anomaly that has been associated with IVC thrombosis (2). We describe a case of extensive IVC thrombosis s...

The human Paf1 complex (Paf1C) subunit Parafibromin assists in mediating output from the Wingless/Int signaling pathway, and dysfunction of the encoding gene HRPT2 conditions specific cancer-related disease phenotypes. Here, we characterize the organismal and molecular roles of PLANT HOMOLOGOUS TO PARAFIBROMIN (PHP), the Arabidopsis (Arabidopsis thaliana) homolog of Parafibromin. PHP resides in...

Primary hyperparathyroidism (PHP) during pregnancy is very rare, and the complications are life threatening and difficult to address. Thus, early diagnosis and appropriate treatment are critical for this disease. We describe a single case of PHP during third trimester pregnancy, which was also combined with hypertension. The patient developed preeclampsia and went into a hypercalcemic crisis; a...

BACKGROUND The acute-phase protein haptoglobin (Hp) and its receptor CD163 serve as immunomodulators and possess anti-inflammatory besides antioxidant functions. OBJECTIVES To further understand the role of the recently described pulmonary Hp (pHp) and its receptor CD163 in case of inflammation and infection, pHp and CD163 were investigated on mRNA and protein level to gain insight into the c...

Pseudohypoparathyroidism (PHP) refers to end-organ resistance that primarily impairs the renal actions of parathyroid hormone (PTH). The patients with PHP type Ia (PHP-Ia), one of the 4 types of PHP, show resistance to other peptide hormones as well as clinical features of Albright hereditary osteodystrophy (AHO), a constellation of short stature, obesity, brachydactyly, ectopic ossifications, ...

OBJECTIVE To assess the risk prevalence of overweight and obesity in children enrolled in private and philanthropic preschools in the State of São Paulo. METHODS Comparison of two cross sectional studies with children enrolled in private preschools (PPS) or philanthropic (PHP) of the São Paulo Metropolitan Region. Both surveys evaluated the children's environment. To determine the risk of ove...

BACKGROUND Physician health programmes (PHPs) are peer-assistance organizations that provide support to physicians struggling with addiction or with physical or mental health challenges. While the services they offer are setting new standards for recovery and care, they are not immune to public debate and criticism since some have concerns about those who are enrolled in, or have completed, suc...