نتایج جستجو برای: peptides

تعداد نتایج: 78712  

Journal: :Synfacts 2023

Key words nickel catalysis - deamination cross-coupling unnatural peptides amino acid pyridinium salts

Introduction: The design and structural characterization of mini-proteins with a compact, folded structure provide insight into the complex architecture of proteins today and has long been a challenging issue in structural- functional studies. Alpha neurotoxins from snake venom have a distinct folded structure comprised of a disulphide core and three loops or “fingers” each of these loops are c...

The bacteria which are members of the genus Bacillus are known to produce a wide variety of antimicrobial substances and bacteriocins. The main objective of this study was to investigate the effect of these bacteriocins on eukaryotic cells such as fungi, yeast and plant seeds. Several strains were screened for antifungal activities and identified by the means of polymerase chain reacti...

Journal: :ACS Bio & Med Chem Au 2023

Amino acid ester prodrugs of the thiazolides, introduced to improve pharmacokinetic parameters parent drugs, proved be stable as their salts but were unstable at pH > 5. Although some instability was due simple hydrolysis, we have found that main end products degradation peptides formed by rearrangement. These solids: they maintained significant antiviral activity, and in general, showed improv...

Journal: :Communications biology 2021

Abstract Our understanding of the activity cationic antimicrobial peptides (AMPs) has focused on well-characterized natural sequences, or limited sets synthetic designed de novo. We have undertaken a comprehensive investigation underlying primary structural features that give rise to development in AMPs. consider complete set all possible peptides, up 7 residues long, composed positively charge...

Journal: :molecular biology research communications 2014
jafar amani parvaneh saffarian shahin najar-pirayeh abbas ali imani-fooladi

clostridium botulinum type a (bont/a) produces a neurotoxin recently found to be useful as an injectable drug for the treatment of abnormal muscle contractions. the catalytic domain of this toxin which is responsible for the main toxin activity is a zinc metalloprotease that inhibits the release of neurotransmitter mediators in neuromuscular junctions. a cell penetrating cationic peptide, tat, ...

Journal: :iranian journal of basic medical sciences 0
maría liliana franco-chuaire departamento de ginecología y obstetricia, hospital mayor mederi, bogotá dc, colombia sandra ramírez-clavijo facultad de ciencias naturales y matemáticas, universidad del rosario, bogotá dc, colombia lilian chuaire-noack facultad de ciencias naturales y matemáticas, universidad del rosario, bogotá dc, colombia

pigment epithelium-derived factor (pedf) is a glycoprotein that belongs to the family of non-inhibitory serpins. the broad spectrum of pedf biological activity is evident when considering its effects in promoting cell survival and proliferation, as well as its antiangiogenic, antitumor, and anti-metastatic properties. although the structural domains of the pedf gene that mediate such diverse ef...

Journal: :Experimental & clinical gastroenterology 2022

Human placenta hydrolysates (HPH) have a pronounced hepatoprotective effect, the molecular mechanisms of which are not well understood. As result de novo mass spectrometric sequencing and bioinformatics analysis peptides, 27 peptides were found in Laennec HPP preparation, (1) support inositol phosphate-dependent signaling pathways hepatocytes, (2) activate target proteins RARA, AMPK, (3) inhibi...

Journal: :Synfacts 2022

Key words potassium fluoride - amino acid deprotection peptides fluorenylmethyl carbamates amides one-pot synthesis

Journal: :Applied sciences 2021

The implementation of peptide-based molecules within the medical field has vast potential, owing to their unique nature and predictable physicochemical profiles. However, peptide therapeutic usage is hindered by delivery-related challenges, meaning that formulations must be altered overcome these limitations. This process could propelled applying microfluidics (MFs) due its highly controllable ...

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