PURPOSE To evaluate serum pepsinogen I (PG I) and gastrin-17 (G-17) levels in patients with Helicobacter pylori (H. pylori)-associated chronic atrophic gastritis, with reference to endoscopical Kimura-Takemoto's staging, chromoendoscopical and histological features. MATERIAL AND METHODS 267 dyspeptic H. pylori-infected patients were examined by chromoendoscopy with biopsy sampling according t...

Pepsinogen has been purified from the fundic mucosa of the dog. The preparation is homogeneous by chromatography, amino terminal analysis, ultracentrifugation, electrophoresis on cellulose acetate strips, and disc electrophoresis. Analysis indicates the presence of 352 amino acid residues, at least 12 moles of carbohydrate including some amino sugars, and 1 mole of organic phosphate per mole of...

reacted with other reactive groups in the protein. However, it would appear that, whatever other reactions may have occurred, the increase in specifically monitors the extent of modification of histidine residues only. Thus diethyl pyrocarbonate appears to have reacted with pig pepsinogen to modify, at least, all three histidine residues in the protein. Once again, therefore, the potential acti...

The aim of this study was to determine the age-specific prevalence of Helicobacter pylori infection in infants and children aged 1-99 months from a poor periurban community in Bangladesh. We also examined the frequency of infection among infants and their 53 immediate family members and evaluated the relationship between infection and fasting serum group II pepsinogen (pepsinogen II) concentrat...

To the Editors: as a comment to the editorial of Oderda et al: In an interesting editorial in this issue of the journal, Oderda et al (1) review which tests may be used to diagnose Helicobacter pylori (H. pylori) in children. Some are invasive (i.e. upper gastro-intestinal endoscopy and multiple gastric biopsies), and some are non invasive (i.e. serology, C-urea breath test and stool antigen de...

Gastric cancer (GC) is one of the most common malignant tumors and the Kazakh population in Xinjiang has been reported to be one of the highest incidence of GC in the world. Serum pepsinogen (PG) test provides a valuable method for detecting GC, but little study about the role of PG in Kazakh GC. Therefore, we aimed to investigate the role of PG in Kazakh GC and to elucidate the usefulness of t...

Ranitidine bismuth citrate was compared with an equipotent dose of ranitidine, to determine whether the former, by an anti-Helicobacter pylori activity, would counteract the rise of gastrin resulting from ranitidine's gastric acid antisecretory activity. Twenty four men with duodenal ulcers were studied before and on the 8th day of dosing with either ranitidine bismuth citrate 800 mg twice dail...

Background—Gastric acid secretion in Japanese subjects decreases with aging. One of the possible causative mechanisms of this attenuated acid secretion is speculated to be a Helicobacter pylori induced chronic gastritis. The infection rate of this microorganism has decreased recently in Japan. Aims—To investigate whether gastric acid secretion has altered over the past 20 years, and if so, what...