A method is described for the evaluation of the speed of onset of i.v. anaesthesia in mice. The technique involves (a) determination of the median hypnotic dose (HD50) by plotting the probit value of the percentage of mice sleeping, against dose on a logarithmic scale, (b) plotting mean induction time over a range of doses against the logarithm of the dose and (c) comparison of induction times ...

2-(0-chlorophenyl)-2-methylaminocyclohexanone (CI-581), a derivative of phencyclidine, was shown to depress the cardiovascular system in conscious rats and in rats anaesthetized with pentobarbitone and urethane. In pithed animals, however, there was a substantial rise in blood pressure, suggesting that CI-581 may act on the central cardiovascular regulatory mechanisms. The pressor response to C...

The dichloromethane fraction of Hedranthera barteri (DMHBR), a common medicinal plant, was investigated in animal models of depression and anxiety in mice. Graded doses (25-200mg/kg p.o. bw) of DMHBR reduced the immobility time with significant effects produced by 50mg/kg (43.7%), 100mg/kg (45.6%) and 200mg/kg (31.5%) in the tail suspension test (TST) and by 100mg/kg (66.3%) in forced swimming ...

Ailanthus excelsa (Stem bark) are used in folk medicine for a treatment of inflammation, arthritis, expectorant, stimulant and asthma. Acute toxicity study of A. excelsa stem bark was performed on mice (Swiss) and albino rats (Wistar strain),given single doses 1,10, 50, 100 ,1000 and 2000mg/kg,po. showed normal behavior and no mortality up to 14 days except 500,1000 and 2000mg/kg dose 20%, 60.0...

Oral administration of the feverfew (Tanacetum parthenium) extract led to significant antinociceptive and anti-inflammatory effects against acetic acid-induced writhing in mice and carrageenan-induced paw edema in rats, respectively. These responses were dose-dependent (10, 20, 40 mg/kg, p.o.). Parthenolide (1, 2 mg/kg i.p.), the active constituent of the extract also produced antinociceptive a...

A STEROID compound 21-hydroxy-preghalf to one hour prior to anaesthesia. A nane-3, 20-dione sodium succinate 4-litre to 2-litre flow of nitrous-oxide (Viadril) has been used as an intravenous oxygen was administered during the placeanaesthetic. The changes in the electroencephalogram produced by this agent have been observed by Boyan et al. (1955) to be similar to the changes reported by Kierse...

1. In an investigation of the prolonged pressor response to renin that develops after nephrectomy, angiotensin I dose-response curves and rat renin clearances were studied in nephrectomized rats and paired sham-nephrectomized control animals under pentobarbitone anaesthesia. 2. Both threshold and slope of the angiotensin I dose-response curves were decreased at 15-27 h after nephrectomy. 3. The...

Maprotiline, a tetracyclic antidepressant drug, was evaluated for antidepressant and neuroleptic activity. In antidepressant tests, maprotiline antagonized reserpine-induced ptosis in rats but, unlike the tricyclic antidepressants, was found to antagonize methamphetamine stereotypy in rats, to decrease the intensity of L-dopa induced behavioural syndrome in pargyline-pretreated mice and to be i...

The importance of neurons in the pontine respiratory group for the generation of cough, expiration, and aspiration reflexes was studied on non-decerebrate spontaneously breathing cats under pentobarbitone anesthesia. The dysfunction of neurons in the pontine respiratory group produced by bilateral microinjection of kainic acid (neurotoxin) regularly abolished the cough reflexes evoked by mechan...

Quinine, is an anti-malarial drug that specifically blocks connexin 36 (Cx36) at gap junction channels. Quinine has suppressed ictal epileptiform activity in vitro without decreasing neuronal excitability. Thus, we considered the possible anticonvulsant effects of quinine in the pentylenetetrazole (PTZ) model of seizure. Moreover, we studied the hypnotic effect and locomotor activity of quinine...